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Impact of Adverse Events on Ventricular Assist Device Outcomes

  • Nonpharmacologic Therapy: Surgery, Ventricular Assist Devices, Biventricular Pacing, and Exercise (AK Hasan, Section Editor)
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Abstract

Left ventricular assist devices have been proven to be superior to medical therapy for advanced heart failure patients awaiting heart transplantation and viable alternatives to transplantation for destination therapy patients. Improvements in the design of ventricular assist devices have been rewarded by a decrease in adverse events and an increase in survival. Despite significant progress, even the latest generation left ventricular assist devices are burdened by a significant long-term adverse events profile that will increasingly challenge physicians as patients survive longer on implantable mechanical circulatory support. In this review, we analyze the impact of long-term adverse events on clinical outcomes in the major trials of continuous flow left ventricular assist devices. We discuss several of the more pertinent and interesting adverse events, examine their potential causes, and explore their future implications.

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Authors and Affiliations

  1. Division of Cardiology, Montefiore Medical Center, 3400 Bainbridge Avenue, Bronx, NY, 10467, USA

    Aleksandar Adzic & Snehal R. Patel

  2. Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    Simon Maybaum

Authors
  1. Aleksandar Adzic
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  2. Snehal R. Patel
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  3. Simon Maybaum
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Corresponding author

Correspondence to Snehal R. Patel.

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Adzic, A., Patel, S.R. & Maybaum, S. Impact of Adverse Events on Ventricular Assist Device Outcomes. Curr Heart Fail Rep 10, 89–100 (2013). https://doi.org/10.1007/s11897-012-0127-3

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  • DOI: https://doi.org/10.1007/s11897-012-0127-3

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