Abstract
Campylobacteriosis is a leading cause of acute infectious diarrhea in the developing world, where it causes considerable mortality, and in developed countries, where it accounts for significant healthcare and other costs. Evidence has emerged from basic science, clinical, and epidemiological domains that suggests that Campylobacter infection is not limited to acute illness but is also involved in the development of well-described extraintestinal sequelae, such as the Guillain–Barré syndrome and reactive arthritis, and may also contribute to the pathogenesis of chronic gastrointestinal conditions. This review will focus on the role of Campylobacter infection as a risk factor for the development of chronic gastrointestinal sequelae, such as functional gastrointestinal disorders, with which irritable bowel syndrome has been most frequently associated, inflammatory bowel disease, and celiac disease.
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The opinions and assertions herein should not be construed as official or representing the views of the Department of the Navy, the Department of Defense, or the U.S. Government. This is a U.S. Government work. There are no restrictions on its use. There were no financial conflicts of interests among any of the authors. E.F.V. is supported by grants from CCFC and CAG/CIHR.
Three of the authors (M.R., R.G., C.P.) are employees of the U.S. Government or military service members. This work was prepared as part of official duties. Title 17 U.S.C. §105 provides that “Copyright protection under this title is not available for any work of the United States Government.” Title 17 U.S.C. §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person’s official duties.
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Riddle, M.S., Gutierrez, R.L., Verdu, E.F. et al. The Chronic Gastrointestinal Consequences Associated With Campylobacter. Curr Gastroenterol Rep 14, 395–405 (2012). https://doi.org/10.1007/s11894-012-0278-0
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DOI: https://doi.org/10.1007/s11894-012-0278-0