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Management and Prognosis of Acute Liver Failure in Children

  • Pediatric Gastroenterology (SR Orenstein, Section Editor)
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Abstract

Although the etiologies of pediatric acute liver failure (ALF) are diverse, ultimate pathophysiologic pathways and management challenges for these disorders, usually lethal in the pre-transplant era, are similar. This review considers particularly the mechanisms of, and monitoring for, intracranial hypertension and coagulopathy; summarizes detailed advice for management of the ALF-associated failures of multiple body systems; and reviews the variety of prognostic scores available to guide management and assist in choosing the patients most apt to benefit from liver transplantation and the optimal timing for such transplantation.

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Authors and Affiliations

  1. Gastroenterology-Hepatology Division, Liver-Intestinal Transplantation Center, Hospital Italiano de Buenos Aires, Gascon 450, CP 1181, Buenos Aires, Argentina

    Daniel D’Agostino, Maria Camila Sanchez & Gustavo Boldrini

  2. Intensive Care Unit. Department of Pediatrics, Hospital Italiano de Buenos Aires, Gascon 450, CP 1181, Buenos Aires, Argentina

    Silvia Diaz

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  1. Daniel D’Agostino
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  2. Silvia Diaz
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  3. Maria Camila Sanchez
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  4. Gustavo Boldrini
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Correspondence to Daniel D’Agostino.

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D’Agostino, D., Diaz, S., Sanchez, M.C. et al. Management and Prognosis of Acute Liver Failure in Children. Curr Gastroenterol Rep 14, 262–269 (2012). https://doi.org/10.1007/s11894-012-0260-x

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  • DOI: https://doi.org/10.1007/s11894-012-0260-x

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