Skip to main content
SpringerLink
Log in

Crying in infant GERD: Acid or volume? Heartburn or dyspepsia?

  • Invited Commentary
  • Published:
Current Gastroenterology Reports Aims and scope Submit manuscript

An infant crying in the night… and with no language but a cry.

Alfred Lord Tennyson In Memoriam A.H.H. 54

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References and Recommended Reading

  1. Ryan P, Lander M, Ong TH, Shepherd R: When does reflux oesophagitis occur with gastro-oesophageal reflux in infants? A clinical and endoscopic study and correlation with outcome. Aust Paediatr J 1983, 19:90–93.

    PubMed  CAS  Google Scholar 

  2. Orenstein SR, Shalaby TM, Cohn JF: Reflux symptoms in 100 normal infants: diagnostic validity of the Infant Gastroesophageal Reflux Questionnaire. Clin Pediatr 1996, 35:607–614.

    Article  CAS  Google Scholar 

  3. Omari TI, Haslam RR, Lundborg P, Davidson GP: Effect of omeprazole on acid gastroesophageal reflux and gastric acidity in preterm infants with pathological acid reflux. J Pediatr Gastroenterol Nutr 2007, 44:41–44.

    PubMed  CAS  Google Scholar 

  4. Moore DJ, Tau BS, Lines DR, et al.: Double-blind placebo-controlled trial of omeprazole in irritable infants with gastroesophageal reflux. J Pediatr 2003, 143:219–223.

    Article  PubMed  CAS  Google Scholar 

  5. Omari T, Davidson G, Bondarov P, et al.: Pharmacokinetics and acid-suppressive effects of esomeprazole in infants 1–24 months old with symptoms of gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr 2007, 45:530–537.

    PubMed  CAS  Google Scholar 

  6. Tran A, Rey E, Pons G, et al.: Pharmacokinetic-pharmacodynamic study of oral lansoprazole in children. Clin Pharmacol Ther 2002, 71:359–367.

    Article  PubMed  CAS  Google Scholar 

  7. Andersson T, Gothberg G, Friberg L, et al.: Pharmacokinetics of intravenous omeprazole in neonates and infants [abstract]. J Pediatr Gastroenterol Nutr 2001, 33:424.

    Google Scholar 

  8. Wessel MA, Cobb CJ, Jackson EB, et al.: Paroxysmal fussing in infancy, sometimes called “colic.” Pediatrics 1954, 14:421.

    PubMed  CAS  Google Scholar 

  9. Treem WR: Infant colic. Pediatr Clin North Am 1994, 41:1121–1138.

    PubMed  CAS  Google Scholar 

  10. Matheson I, Rivrud GN: The effect of smoking on lactation and infantile colic. JAMA 1989, 261:42–43.

    Article  PubMed  CAS  Google Scholar 

  11. Said G, Patois E, Lellouch J: Infantile colic and parental smoking. Br Med J (Clin Res Ed) 1984, 289:660.

    CAS  Google Scholar 

  12. Sutphen JL: Is it colic or is it gastroesophageal reflux? J Pediatr Gastroenterol Nutr 2001, 33:110–111.

    Article  PubMed  CAS  Google Scholar 

  13. Barron JJ, Tan H, Spalding J, et al.: Proton pump inhibitor utilization patterns in infants. J Pediatr Gastroenterol Nutr 2007, 45:421–427.

    PubMed  CAS  Google Scholar 

  14. Orenstein SR, Hassall E: Infants and proton pump inhibitors: tribulations, no trials [editorial]. J Pediatr Gastroenterol Nutr 2007, 45:395–398.

    Article  PubMed  Google Scholar 

  15. Feranchak AP, Orenstein SR, Cohn JF: Behaviors associated with onset of gastroesophageal reflux episodes in infants: prospective study using split-screen video and pH probe. Clin Pediatr 1994, 33:654–662.

    Article  CAS  Google Scholar 

  16. Condino AA, Sondheimer J, Pan Z, et al.: Evaluation of infantile acid and nonacid gastroesophageal reflux using combined pH monitoring and impedance measurement. J Pediatr Gastroenterol Nutr 2006, 42:16–21.

    Article  PubMed  Google Scholar 

  17. Ravelli A, Villanacci V, Ruzzenenti N, et al.: Dilated intercellular spaces: a major morphological feature of esophagitis. J Pediatr Gastroenterol Nutr 2006, 42:510–515.

    Article  PubMed  Google Scholar 

  18. Orlando RC: Current understanding of the mechanisms of gastro-oesophageal reflux disease [review]. Drugs 2006, 66(Suppl 1):1–5.

    PubMed  CAS  Google Scholar 

  19. Sabri MT, Hussain SZ, Shalaby TM, Orenstein SR: Morphometric histology for infant gastroesophageal reflux disease: evaluation of reliability in 497 esophageal biopsies. J Pediatr Gastroenterol Nutr 2007, 44:27–34.

    Article  PubMed  Google Scholar 

  20. Orenstein SR: Infantile reflux: different from adult reflux. Am J Med 1997, 103(5A):114S–119S.

    Article  PubMed  CAS  Google Scholar 

  21. Orenstein SR, Dent J, Deneault LG, et al.: Regurgitant reflux, vs. non-regurgitant reflux, is preceded by rectus abdominis contraction in infants. Neurogastroenterol Motil 1994, 6:271–277.

    Google Scholar 

  22. Black DD, Haggitt RC, Orenstein SR, Whitington PF: Esophagitis in infants: morphometric histologic diagnosis and correlation with measures of gastroesophageal reflux. Gastroenterology 1990, 98:1408–1414.

    PubMed  CAS  Google Scholar 

  23. Shalaby TM, Orenstein SR: Efficacy of telephone teaching of conservative therapy for infants with symptomatic gastroesophageal reflux referred by pediatricians to pediatric gastroenterologists. J Pediatr 2003, 142:57–61.

    Article  PubMed  Google Scholar 

  24. Orenstein SR, McGowan JD: Efficacy of conservative therapy as taught in the primary care setting for symptoms suggesting infant gastroesophageal reflux: prospective validated assessment by the I-GERQ-R. J Pediatr 2008, 152:310–314.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Pittsburgh School of Medicine, 303 Church Lane, Pittsburgh, PA, 15238, USA

    Susan R. Orenstein

Authors
  1. Susan R. Orenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susan R. Orenstein.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Orenstein, S.R. Crying in infant GERD: Acid or volume? Heartburn or dyspepsia?. Curr Gastroenterol Rep 10, 433–436 (2008). https://doi.org/10.1007/s11894-008-0080-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11894-008-0080-1

Keywords

Search

Navigation