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Depression in Youth-Onset Type 2 Diabetes

  • Pediatric Type 2 and Monogenic Diabetes (O Pinhas-Hamiel, Section Editor)
  • Published:
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Abstract

Purpose of Review

The current review summarizes extant knowledge regarding the prevalence of depression in youth-onset type 2 diabetes (T2D) and how depression might impact glycemic control through stress-related behavioral and physiological mechanisms. The current review also discusses depression intervention studies in adult-onset T2D, as there are no such studies in youth-onset T2D, and provides recommendations for clinical research.

Recent Findings

The prevalence of elevated depression symptoms in youth-onset T2D is approximately 20%. Some studies suggest depression may negatively impact glycemic control through inadequate medication adherence and disordered eating, but there is a dearth of studies investigating associations with depression and physical activity/sedentary time, sleep, and stress-related physiological mechanisms. In adult-onset T2D, evidence-based behavioral interventions tailored to address diabetes-related issues have shown positive effects for depression and glycemic control.

Summary

Future research is needed to characterize the epidemiology of depression in youth-onset T2D and test interventions to improve depression, glycemic control, and health outcomes in this specific pediatric population.

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Funding

This review was partially supported by R01DK111604 from the National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health.

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Authors and Affiliations

  1. Department of Human Development and Family Studies, College of Health and Human Sciences, Colorado State University, 1570 Campus Delivery, Fort Collins, CO, 80523, USA

    Lauren D. Gulley & Lauren B. Shomaker

  2. Section of Endocrinology, Department of Pediatrics, University of Colorado School of Medicine/Anschutz Medical Campus and Children’s Hospital Colorado, 13123 E 16th Avenue, B265, Aurora, CO, 80045, USA

    Lauren D. Gulley & Lauren B. Shomaker

  3. Department of Community and Behavioral Health, Colorado School of Public Health, Aurora, CO, USA

    Lauren B. Shomaker

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Correspondence to Lauren D. Gulley.

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This article is part of the Topical Collection on Pediatric Type 2 and Monogenic Diabetes

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Gulley, L.D., Shomaker, L.B. Depression in Youth-Onset Type 2 Diabetes. Curr Diab Rep 20, 51 (2020). https://doi.org/10.1007/s11892-020-01334-8

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