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Inpatient Glycemic Management of the Pregnant Patient

  • Hospital Management of Diabetes (A Wallia and JJ Seley, Section Editors)
  • Published:
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Abstract

Purpose of Review

There is a rising prevalence of type 1 diabetes (T1DM), type 2 diabetes (T2DM), and gestational diabetes (GDM) in pregnancy. Reaching and maintaining glycemic targets during and after this time are important for both the health of the mother and her baby.

Recent Findings

Based on recently published guidelines from various societies, we review the diagnosis of diabetes in pregnancy, types of therapies available to maintain euglycemia, important keys to management of T1DM, T2DM, and GDM, and strategies for reaching inpatient glycemic targets during the peripartum period. Care for pregnant patients with T1DM is especially challenging, and providers should be aware of the varying insulin requirements at different stages of pregnancy and how to reduce hypoglycemia and avoid diabetic ketoacidosis. Insulin sensitivity fluctuates throughout pregnancy due to physiologic changes, especially during labor and delivery and immediately post-partum. We review recommendations regarding how to manage this dynamic time and present our own institution’s inpatient management protocol. Finally, we review management of diabetes post-partum, including medications, breast-feeding, and continued monitoring and screening.

Summary

With the collaborative efforts of the patient and an interdisciplinary team and in-depth knowledge of the most up-to-date management principles, it is possible to achieve euglycemia during this critical time of a mother and baby’s life.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. •• Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus. Obstet Gynecol. 2018;131(2):e49–64. The latest guidelines on the management of gestational diabetes in pregnancy from the American College of Obstetricians and Gynecologists.

    Article  Google Scholar 

  2. Kitzmiller JL, Buchanan TA, Kjos S, Combs CA, Ratner RE. Pre-conception care of diabetes, congenital malformations, and spontaneous abortions. Diabetes Care. 1996;19(5):514–41.

    Article  CAS  PubMed  Google Scholar 

  3. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290–6.

    Article  PubMed  Google Scholar 

  4. Lawlor DA, Fraser A, Lindsay RS, Ness A, Dabelea D, Catalano P, et al. Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia. 2010;53(1):89–97.

    Article  CAS  PubMed  Google Scholar 

  5. •• Blumer I, Hadar E, Hadden DR, Jovanovič L, Mestman JH, Murad MH, et al. Diabetes and pregnancy: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(11):4227–49. The latest guidelines on diabetes management in pregnancy from the Endocrine Society.

    Article  CAS  PubMed  Google Scholar 

  6. Hernandez TL, Friedman JE, Van Pelt RE, Barbour LA. Patterns of Glycemia in normal pregnancy: should the current therapeutic targets be challenged? Diabetes Care. 2011;34:1660–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Harmon KA, Gerard L, Jensen DR, Kealey EH, Hernandez TL, Reece MS, et al. Continuous glucose profiles in obese and normal-weight pregnant women on a controlled diet: metabolic determinants of fetal growth. Diabetes Care. 2011;34:2198–204.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Coombs CA, Moses RG. Aiming at new targets to achieve Normoglycemia during pregnancy. Diabetes Care. 2011;34(10):2331–2.

    Article  Google Scholar 

  9. Shields, L and Tsay, GS. Editors, California Diabetes and Pregnancy Program Sweet Success Guidelines for Care. Developed with California Department of Public Health; Maternal Child and Adolescent Health Division; revised edition, updated September 2015.

  10. Jovanovic L, Knopp RH, Brown Z, Conley MR, Park E, Mills JL, et al. Declining insulin requirement in the late first trimester of diabetic pregnancy. Diabetes Care. 2001;24(7):1130–6.

    Article  CAS  PubMed  Google Scholar 

  11. •• ADA 13. Management of Diabetes in Pregnancy. Diabetes Care. 2018;41(Suppl 1):S137–S43. The latest guidelines on diabetes management in pregnancy from the American Diabetes Association.

    Google Scholar 

  12. • Garrison EA, Jagasia S. Inpatient management of women with gestational and pregestational diabetes in pregnancy. Curr Diab Rep. 2014;14(2):457. A comprehensive review of inpatient gestational diabetes management in 2014.

    Article  CAS  PubMed  Google Scholar 

  13. Hashimoto K, Masafumi K. Indicators of glycemic control in patients with gestational diabetes mellitus and pregnant women with diabetes mellitus. World J Diabetes. 2015;6(8):1045–56.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ozgu-Erdinc AS, Iskender C, Uygur D, Oksuzoglu A, Seckin KD, Yeral MI, et al. One-hour versus two-hour postprandial blood glucose measurement in women with gestational diabetes mellitus: which is more predictive? Endocrine. 2016;52(3):561–70.

    Article  CAS  PubMed  Google Scholar 

  15. Moses RG, Lucas EM, Knights S. Gestational diabetes mellitus. At what time should the postprandial glucose level be monitored? Aust NZ J Obstet Gynaecol. 1999;39(4):457–60.

    Article  CAS  Google Scholar 

  16. Goedegebure EAR, Koning SH, Hoogenberg K, Korteweg FJ, Lutgers HL, Diekman MJM, et al. Pregnancy outcomes in women with gestational diabetes mellitus diagnosed according to the WHO-2013 and WHO-1999 diagnostic criteria: a multicenter retrospective cohort study. BMC Pregnancy Childbirth. 2018;18:152.

    Article  PubMed  PubMed Central  Google Scholar 

  17. ADA 2. Classification and Diagnosis of Diabetes. Diabetes Care. 2018;41(Suppl 1):S137–S43.

    Google Scholar 

  18. Lee GT, Satyan MT, Grothusen JD, et al. A retrospective study comparing outcomes in a midwestern US population after introduction of IADPSG guidelines for gestational diabetes. J Matern Fetal Neonatal Med. 2017; Sep 6:1–6.

  19. Hernandez TL, Anderson MA, Chartier-Logan C, Friedman JE, Barbour LA. Strategies in the nutritional management of gestational diabetes. Clin Obstet Gynecol. 2013;56(4):803–15.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Colberg SR, Castorino K, Jovanovic L. Prescribing physical activity to prevent and manage gestational diabetes. World J Diabetes. 2013;4(6):256–62.

    Article  PubMed  PubMed Central  Google Scholar 

  21. • Blum AK. Insulin use in pregnancy: an update. Diabetes Spectr. 2016;29(2):92–7. A comprehensive summary of the use of insulins in pregnancy.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Food and Drug Administration (FDA). Content and Format of Labeling for Human Prescription Drug and Biological Products; Requirements for Pregnancy and Lactation Labeling. 79 FR 72063. https://www.federalregister.gov/d/2014-28241.

  23. Gallen IW, Jaap A, Roland JM, Chirayath HH. Survey of glargine use in 115 pregnant women with type 1 diabetes. Diabet Med. 2008;25(2):165–9.

    Article  CAS  PubMed  Google Scholar 

  24. Vague P, Selam JL, Skeie S, De Leeuw I, et al. Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart. Diabetes Care. 2003;26(3):590–6.

    Article  CAS  PubMed  Google Scholar 

  25. Okeigwe I, Yeaton-Massey A, Kim S, Vargas JE, Murphy EJ. U-500R and aspart insulin for the treatment of severe insulin resistance in pregnancy associated with pregestational diabetes. J Perinatol. 2013;33(3):235–8.

    Article  CAS  PubMed  Google Scholar 

  26. Zuckerwise LC, Werner EF, Pettker CM, McMahon-Brown EK, Thung SF, Han CS. Pregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancy. Obstet Gynecol. 2012;120(2 Pt 2):439–42.

    Article  CAS  PubMed  Google Scholar 

  27. • Kalra B, Gupta Y, Singla R, Kalra S. Use of Oral Anti-Diabetic Agents in Pregnancy: A Pragmatic Approach. N Am J Med Sci. 2015;7(1):6–12. An evidence-based review of oral anti-diabetic agents and their use in pregnancy.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Rowan JA, Hague WM, Gao W, Battin MR. Moore MP; MiG trial investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med. 2008;358(19):2003–15.

    Article  CAS  PubMed  Google Scholar 

  29. Gui J, Liu Q, Feng L. Metformin vs insulin in the management of gestational diabetes: a meta-analysis. PLoS One. 2013;8(5):e64585.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. •• Butalia S, Gutierrez L, Lodha A, Aitken E, Zakariasen A, Donovan L. Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis. Diabet Med. 2017;34:27–36. A meta-analysis that showed that metformin had no short-term adverse effects on pregnancy.

    Article  CAS  PubMed  Google Scholar 

  31. Langer O, Yogev Y, Xenakis EM, Rosenn B. Insulin and glyburide therapy: dosage, severity level of gestational diabetes, and pregnancy outcome. Am J Obstet Gynecol. 2005;192(1):134–9.

    Article  CAS  PubMed  Google Scholar 

  32. Langer O, Conway DL, Berkus MD, Xenakis EM, Gonzales O. A comparison of glyburide and insulin in women with gestational diabetes mellitus. N Engl J Med. 2000;343(16):1134–8.

    Article  CAS  PubMed  Google Scholar 

  33. Song R, Chen L, Chen Y, Si X, Liu Y, Liu Y, et al. Comparison of glyburide and insulin in the management of gestational diabetes: a meta-analysis. PLoS One. 2017;12:e0182488.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. •• Balsells M, Garcia-Patterson A, Sola I, Roque M, Gich I, Corcoy R. Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. BMJ. 2015;350:h102. A meta-analysis showing that when treating women with gestational diabetes, glibenclamide (glyburide) is inferior to both insulin and metformin.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Vargas R, Repke JT, Ural SH. Type 1 diabetes mellitus and pregnancy. Rev Obstet Gynecol. 2010;3(3):92–100.

    PubMed  PubMed Central  Google Scholar 

  36. • Modi A, Agrawal A, Morgan F. Euglycemic Diabetic Ketoacidosis: A Review. Curr Diabetes Rev. 2017;13(3):315–21. An article reviewing the etiologies, pathophysiology, diagnosis and management of euglycemic DKA.

    Article  CAS  PubMed  Google Scholar 

  37. Rawla P, Vellipuram AR, Bandaru SS, Pradeep RJ. Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma. Endocrinol Diabetes Metab Case Rep. 2017;2017

  38. New York–Presbyterian Hospital. Diabetic Ketoacidosis Guidelines. New York, NY, NewYork–Presbyterian Hospital, Cornell Campuses, June 2017.

  39. McCarthy FP, Lutomski JE, Greene RA. Hyperemesis gravidarum: current perspectives. Int J Womens Health. 2014;6:719–25.

    PubMed  PubMed Central  Google Scholar 

  40. London V, Grube S, Sherer DM, Abulafia O. Hyperemesis Gravidarum: a review of recent literature. Pharmacology. 2017;100:161–71.

    Article  CAS  PubMed  Google Scholar 

  41. Feldman AZ, Brown FM. Management of Type 1 diabetes in pregnancy. Curr Diab Rep. 2016;16(8):76.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Frise CJ, Mackillop L, Joash K, Williamson C. Starvation ketoacidosis in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013;167(1):1–7.

    Article  PubMed  Google Scholar 

  43. Scott EM, Bilous RW, Kautzky-Willer A. Accuracy, user acceptability, and safety evaluation for the FreeStyle libre flash glucose monitoring system when used by pregnant women with diabetes. Diabetes Technol Ther. 2018;20(3):180–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. New York–Presbyterian Hospital. Insulin Pump, Patient’s Own, Adult. New York, NY, NewYork–Presbyterian Hospital, Cornell Campuses, June 2017.

  45. Dude A, Niznik CM, Szmuilowicz ED, Peaceman AM, Yee LM. Management of diabetes in the intrapartum and postpartum patient. Am J Perinatol. 2018.

  46. Achong N, Duncan EL, McIntyre HD, Callaway L. Peripartum management of glycemia in women with type 1 diabetes. Diabetes Care. 2014;37(2):364–71.

    Article  PubMed  Google Scholar 

  47. Drever E, Tomlinson G, Bai AD, Feig DS. Insulin pump use compared with intravenous insulin during labour and delivery: the INSPIRED observational cohort study. Diabet Med. 2016;33(9):1253–9.

    Article  CAS  PubMed  Google Scholar 

  48. New York–Presbyterian Hospital. Insulin Infusion During the Peripartum Period. New York, NY, NewYork–Presbyterian Hospital, Cornell Campuses, June 2017.

  49. ADA 14: Diabetes Care in the Hospital: Standards of Medical Care in Diabetes – 2018. Diabetes Care 2018 Jan; 41(Supplement 1): S144-S151.

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Correspondence to Felicia A. Mendelsohn Curanaj.

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Conflict of Interest

Tiffany Yeh, Michele Yeung, and Felicia A. Mendelsohn Curanaj declare that they have no conflicts of interest.

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This study does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Hospital Management of Diabetes

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Yeh, T., Yeung, M. & Mendelsohn Curanaj, F.A. Inpatient Glycemic Management of the Pregnant Patient. Curr Diab Rep 18, 73 (2018). https://doi.org/10.1007/s11892-018-1045-x

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  • DOI: https://doi.org/10.1007/s11892-018-1045-x

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