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Islet Versus Pancreas Transplantation in Type 1 Diabetes: Competitive or Complementary?

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Abstract

Whole organ pancreas and pancreatic islet transplantation are currently the only forms of clinically available β-cell replacement. Both therapeutic options can provide good glycemic control and prevention or stabilization of diabetic complications, but at the price of permanent immunosuppression. Therefore, the indication for transplantation of type 1 diabetes patients must be balanced carefully and should be restricted to a subgroup of patients with extreme lability of metabolic control and frequent hypoglycemia despite optimal medical therapy.

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Authors and Affiliations

  1. Department of Medicine III, University Hospital Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Germany

    Barbara Ludwig, Anja Steffen & Stefan R. Bornstein

  2. Paul Langerhans Institute Dresden, Dresden, Germany

    Barbara Ludwig, Anja Steffen, Hans-Detlev Saeger & Stefan R. Bornstein

  3. Department of General, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Germany

    Stefan Ludwig & Hans-Detlev Saeger

Authors
  1. Barbara Ludwig
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  2. Stefan Ludwig
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  3. Anja Steffen
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  4. Hans-Detlev Saeger
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  5. Stefan R. Bornstein
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Correspondence to Barbara Ludwig.

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Ludwig, B., Ludwig, S., Steffen, A. et al. Islet Versus Pancreas Transplantation in Type 1 Diabetes: Competitive or Complementary?. Curr Diab Rep 10, 506–511 (2010). https://doi.org/10.1007/s11892-010-0146-y

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  • DOI: https://doi.org/10.1007/s11892-010-0146-y

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