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Risk of T2DM and impaired fasting glucose among pcos subjects: Results of an 8-year follow-up

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Abstract

Women with polycystic ovary syndrome (PCOS) often develop type 2 diabetes mellitus (T2DM). To determine the magnitude of risk of developing T2DM among women with PCOS, development of T2DM was prospectively assessed among women who had T2DM (n = 97) and controls (n = 95) using Kaplan-Meier survival analysis and Cox proportional hazards modeling. The women with T2DM had higher baseline weight (body mass index, P < 0.01) and lower insulin sensitivity (homeostasis assessment model of insulin resistance, P < 0.01). The 8-year incidence rate among cases and controls was 13.4% and 5.8%, respectively (relative risk = 2.3). Obese cases had a fivefold risk of T2DM developing (P < 0.01) compared with age-adjusted obese controls, indicating significant interaction between PCOS and obesity to effect T2DM risk.

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Authors and Affiliations

  1. Department of Epidemiology, University of Pittsburgh, A526 Crabtree Hall, 130 DeSoto Street, 15261, Pittsburgh, PA, USA

    Evelyn O. Talbott DrPH, MPH

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  1. Monique Y. Boudreaux PhD
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  2. Evelyn O. Talbott DrPH, MPH
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  3. Kevin E. Kip PhD
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  4. Maria M. Brooks PhD
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  5. Selma F. Witchel MD
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Correspondence to Evelyn O. Talbott DrPH, MPH.

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Boudreaux, M.Y., Talbott, E.O., Kip, K.E. et al. Risk of T2DM and impaired fasting glucose among pcos subjects: Results of an 8-year follow-up. Curr Diab Rep 6, 77–83 (2006). https://doi.org/10.1007/s11892-006-0056-1

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