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Utilizing the GLP-1 signaling system to treat diabetes: Sorting through the pharmacologic approaches

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Abstract

cagon-like peptide-1 (GLP-1) is an intestinal hormone that promotes glucose homeostasis through the regulation of insulin and glucagon secretion, gastric emptying, and food intake. This spectrum of effects makes GLP-1 an attractive candidate for drug development. However, because GLP-1 is a small peptide with rapid metabolism in the circulation, its usefulness to treat patients is limited. However, GLP-1 mimetics that are resistant to degradation have been developed and are effective in lowering blood glucose in diabetic patients. A second strategy for harnessing GLP-1 therapeutically is to inhibit the metabolism of endogenous GLP-1; several orally available compounds are in clinical trials. These two new classes of drugs both enhance GLP-1 signaling but differ in several key characteristics that may lead to distinct roles in the treatment of diabetic patients.

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  1. Division of Endocrinology/Metabolism, University of Cincinnati, Vontz Center, 3125 Eden Avenue, ML 0547, 45220-0547, Cincinnati, OH, USA

    David A. D’Alessio MD & Torsten P. Vahl MD

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  1. David A. D’Alessio MD
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  2. Torsten P. Vahl MD
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D’Alessio, D.A., Vahl, T.P. Utilizing the GLP-1 signaling system to treat diabetes: Sorting through the pharmacologic approaches. Curr Diab Rep 5, 346–352 (2005). https://doi.org/10.1007/s11892-005-0092-2

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