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The genetics of adiponectin

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Abstract

Adiponectin encoded by the APM1 gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APM 1 gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APM 1 gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APM 1 gene and questions that genetic data raise.

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Authors and Affiliations

  1. CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur de Lille, I rue du Docteur Calmette, BP447, F-59021, Lille cedex, France

    Francis Vasseur PhD, Frédéric Leprêtre PhD & Philippe Froguel MD, PhD

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  1. Francis Vasseur PhD
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  2. Frédéric Leprêtre PhD
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  3. Corinne Lacquemant PhD
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  4. Philippe Froguel MD, PhD
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Vasseur, F., Leprêtre, F., Lacquemant, C. et al. The genetics of adiponectin. Curr Diab Rep 3, 151–158 (2003). https://doi.org/10.1007/s11892-003-0039-4

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