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Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes

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Abstract

Experimental and epidemiologic studies support the role of inflammation in the development of type 2 diabetes and atherosclerosis. Serum levels of inflammatory markers, in particular highly sensitive C-reactive protein, have been found to be strong predictors of increased risk for type 2 diabetes and cardiovascular disease independent of traditional risk factors. A beneficial effect of thiazolidinediones, angiotensin-converting enzyme inhibitors, and statins in the prevention of type 2 diabetes and cardiovascular events has recently been reported, and potential anti-inflammatory mechanisms of action for these compounds have been described. Prospective, randomized clinical trials are currently underway to confirm these initial findings and define indications for treatment of patients at risk.

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  1. Division of Endocrinology and Metabolism, University of Virginia, Fontaine Research Park, 450 Ray C. Hunt Drive, Fontaine Medical Research Building, 1st Floor Room #1220, P.O. Box 801405, 22908-1405, Charlottesville, VA, USA

    Milagros G. Huerta MD & Jerry L. Nadler MD

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  1. Milagros G. Huerta MD
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  2. Jerry L. Nadler MD
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Huerta, M.G., Nadler, J.L. Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes. Curr Diab Rep 2, 396–402 (2002). https://doi.org/10.1007/s11892-002-0103-5

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