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Novel Therapies for Critical Limb-Threatening Ischemia

  • New Therapies for Cardiovascular Disease (AA Bavry and MR Massoomi, Section Editors)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review intends to discuss the latest endovascular and surgical advancement in the treatment of critical limb-threatening ischemia (CLTI).

Recent Findings

We discuss novel endovascular technological advancements such as intravascular lithotripsy, the Tack endovascular stent, the PQ Bypass DETOUR system, and the LimFlow System for deep venous arterialization (DVA) in the very high risk “no-option” CLTI population. We also discuss the increasing adoption of radial and pedal approaches for endovascular revascularization and the tibiopedal arterial minimally invasive (TAMI) technique. On the surgical front, we discuss the distal vein patch technique and surgical and hybrid DVA.

Summary

Recent advancements in the treatment options of CLTI will likely lead to reducing the rate of major amputations if they are adopted in a collaborative environment in order to apply the most appropriate treatment option to each individual patient based on the anatomy, comorbidities, functional status, and local expertise.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Carient Heart and Vascular, Manassas, VA, 20109, USA

    Ashkan Karimi & Behdad Aryavand

  2. Walter Reed National Military Medical Center, Bethesda, MD, 20889, USA

    Alexis L. Lauria

  3. Department of Surgery, INOVA Heart and Vascular Institute, Falls Church, VA, 22042, USA

    Richard F. Neville

Authors
  1. Ashkan Karimi
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  2. Alexis L. Lauria
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  3. Behdad Aryavand
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  4. Richard F. Neville
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Corresponding author

Correspondence to Ashkan Karimi.

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ConsentConflict of Interest

Richard F. Neville reports being on the Scientific Advisory board for WL Gore, outside the submitted work.

The other authors do not have any financial disclosures relevant to the content of this article.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on New Therapies for Cardiovascular Disease

Supplementary Information

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Supplementary file1 Revascularization of a completely occluded superficial femoral artery via retrograde approach. After successful crossing and intravascular interrogation of the occluded segment, there was only dissection at the ostium of the superficial femoral artery at the retrograde reentry site, which was treated with 1 Tack stent leaving only 6 mm length of the metal footprint (MP4 19049 KB)

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Karimi, A., Lauria, A.L., Aryavand, B. et al. Novel Therapies for Critical Limb-Threatening Ischemia. Curr Cardiol Rep 24, 513–517 (2022). https://doi.org/10.1007/s11886-022-01669-6

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  • DOI: https://doi.org/10.1007/s11886-022-01669-6

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