Skip to main content
Log in

Pericardial Cysts: a Contemporary Comprehensive Review

  • Pericardial Disease (AL Klein and CL Jellis, Section Editors)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This is an in-depth review on the etiology, clinical manifestation, differential diagnosis, diagnostic modalities, complications, and management of pericardial cysts (PCs).

Recent Findings

PCs are the third most common type of mediastinal masses and are usually identified incidentally by chest x-ray (CXR) or transthoracic echocardiography (TTE). Although most PCs are asymptomatic, they might lead to serious complications such as cardiac tamponade. Diagnosis is confirmed by cardiac computed tomography or cardiac magnetic resonance. Cysts need to be followed by imaging every 1 to 2 years; however, a recent report suggested less frequent follow-up. Most cases resolve spontaneously, but if needed, aspiration or surgical resection can be done.

Summary

PCs are rare entities and are usually detected incidentally after CXR or TTE. Providers should be aware of this condition since it could potentially lead to serious complications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Chihara RK, Force SD. Laparoscopic approach for treatment of symptomatic intra-pericardial cyst. Ann Thorac Surg. 2017;104:e137–8. https://doi.org/10.1016/j.athoracsur.2017.02.081. This study provides a comprehensive approach on the minimal invasive therapy for pericardial cysts.

    Article  Google Scholar 

  2. Tower-Rader A, Kwon D. Pericardial masses, cysts and diverticula: a comprehensive review using multimodality imaging. Prog Cardiovasc Dis. 2017;59:389–97. https://doi.org/10.1016/j.pcad.2016.12.011.

    Article  PubMed  Google Scholar 

  3. DE Roover P, Maisin J, Lacquet A. Congenital pleuropericardial cysts. Thorax. 1963;18:146–50. https://doi.org/10.1136/thx.18.2.146.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Patel J, Park C, Michaels J, Rosen S, Kort S. Pericardial cyst: case reports and a literature review. Echocardiography. 2004;21:269–72. https://doi.org/10.1111/j.0742-2822.2004.03097.x.

    Article  PubMed  Google Scholar 

  5. Cohen AJ, Thompson LN, Edwards FH, Bellamy RF. Primary cysts and tumors of the mediastinum. Ann Thorac Surg. 1991;51:378–86. https://doi.org/10.1016/0003-4975(91)90848-K.

    Article  CAS  PubMed  Google Scholar 

  6. Lennon Collins K, Zakharious F, Mandal A, Missouris C. Pericardial cyst: never too late to diagnose. J Clin Med. 2018;7(11):399. https://doi.org/10.3390/jcm7110399.

    Article  PubMed Central  Google Scholar 

  7. Moffa AP, Stoppino LP, Loizzi D, Milillo P. Spontaneous disappearance of a pericardial cyst: case report and literature review. Korean J Thorac Cardiovasc Surg. 2018;51:72–5. https://doi.org/10.5090/kjtcs.2018.51.1.72.

    Article  PubMed  PubMed Central  Google Scholar 

  8. •• Alkharabsheh S, Gentry JL, Khayata M, et al. Clinical Features, Natural History, and Management of Pericardial Cysts. Am J Cardiol. 2019; https://doi.org/10.1016/j.amjcard.2018.09.009. This study provides a thorough review on the clinical manifistation, diagnostic modalities, and management of pericardial cysts.

    Article  Google Scholar 

  9. Abbey AM, Flores RM. Spontaneous resolution of a pericardial cyst. Ann Thorac Cardiovasc Surg. 2010;16(1):55–6.

  10. Oguri M, Ohguchi S, Takahara K, Kawamura Y, Yokoi Y, Izumi K, et al. Hemorrhagic pericardial cyst complicated with constrictive pericarditis. Intern Med. 2018;57(24):3565–8. https://doi.org/10.2169/internalmedicine.1047-18.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Park M, Kim GJ. Prenatal sonographic diagnosis of a pericardial cyst. J Ultrasound Med. 2015;34:739–41. https://doi.org/10.7863/ultra.34.4.739.

    Article  PubMed  Google Scholar 

  12. Mejía Lozano P, Pérez Ortiz E, Puchaes Manchón C. Cardiac tamponade due to a pleuropericardial cyst with invasive lung cancer. Arch Bronconeumol. 2010;46:658–9. https://doi.org/10.1016/S1579-2129(10)70142-7.

    Article  PubMed  Google Scholar 

  13. •• Adler Y, Charron P. The 2015 ESC guidelines on the diagnosis and management of pericardial diseases. Eur Heart J. 2015:2873–85. https://doi.org/10.1093/eurheartj/ehv479. This report provides the guidelines for the management of pericardial diseases.

  14. Saldana Duenas C, Hernandez Galan A. Posttraumatic pericardial cyst. An Sist Sanit Navar. 2015.

  15. Franco-Paredes C, Rouphael N, Méndez J, Folch E, Rodríguez-Morales AJ, Santos JI, et al. Cardiac manifestations of parasitic infections part 3: pericardial and miscellaneous cardiopulmonary manifestations. Clin Cardiol. 2007;30:277–80. https://doi.org/10.1002/clc.20092.

    Article  PubMed  Google Scholar 

  16. Lin T-H, Chiu C-C, Huang C-H, Tsai K-B, Sheu S-H. Tuberculous pericardial abscess: a case report. Kaohsiung J Med Sci. 2005;21:322–5. https://doi.org/10.1016/s1607-551x(09)70128-7.

    Article  PubMed  Google Scholar 

  17. Lococo F, Charpentier MC, Guinet C, Brandolini J, Alifano M, Regnard JF. Mediastinal recurrence from ovarian cystadenocarcinoma presenting as pleuro-pericardial cyst. Eur Rev Med Pharmacol Sci. 2014;18(15):2094–6.

  18. Najib MQ, Chaliki HP, Raizada A, Ganji JL, Panse PM, Click RL. Symptomatic pericardial cyst: a case series. Eur J Echocardiogr. 2011;12:E43. https://doi.org/10.1093/ejechocard/jer160.

    Article  PubMed  Google Scholar 

  19. Shin MS, Ho KJ. Spontaneous radiographic resolution of malignant and benign cysts. J Comput Tomogr. 1986;10:99–106. https://doi.org/10.1016/0149-936X(86)90021-4.

    Article  CAS  PubMed  Google Scholar 

  20. Sahni DR, Vijayanagar SG, Bala RK, Sabharwal VK. An atypical presentation of a pericardial cyst. Oxford Med Case Reports. 2017;2017(11):229–32. https://doi.org/10.1093/omcr/omx075.

    Article  Google Scholar 

  21. Amr BS, Dalia T, Simmons A. Acute cardiac tamponade secondary to ruptured pericardial cyst: case report and literature review. J Cardiol Cases. 2018;18:43–6. https://doi.org/10.1016/j.jccase.2018.04.003.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Bernasconi A, Yoo SJ, Golding F, Langer JC, Jaeggi ET. Etiology and outcome of prenatally detected paracardial cystic lesions: a case series and review of the literature. Ultrasound Obstet Gynecol. 2007;29:388–94. https://doi.org/10.1002/uog.3963.

    Article  CAS  PubMed  Google Scholar 

  23. Klein AL, Abbara S, Agler DA, Appleton CP, Asher CR, Hoit B, et al. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease: endorsed by the Society for Cardiovascular Magnetic Resonance and Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr. 2013;26:965–1012.e15. https://doi.org/10.1016/j.echo.2013.06.023.

    Article  PubMed  Google Scholar 

  24. Fortuny E, Fernandez-Golfin C, Viliani D, Zamorano JL. Multimodality imaging in pericardial diseases. J Cardiovasc Echogr. 2012;22:1–10. https://doi.org/10.1016/j.jcecho.2011.09.004.

    Article  Google Scholar 

  25. Antonini-Canterin F, Piazza R, Ascione L, Pavan D, Nicolosi GL. Value of transesophageal echocardiography in the diagnosis of compressive, atypically located pericardial cysts. J Am Soc Echocardiogr. 2002;15:192–4. https://doi.org/10.1067/mje.2002.117537.

    Article  PubMed  Google Scholar 

  26. Rajiah P, Kanne JP, Kalahasti V, Schoenhagen P. Computed tomography of cardiac and pericardiac masses. J Cardiovasc Comput Tomogr. 2011;5:16–29. https://doi.org/10.1016/j.jcct.2010.08.009.

    Article  PubMed  Google Scholar 

  27. Verhaert D, Gabrie RS, Johnston D, Lytle BW, Desai MY, Klein AL. The role of multimodality imaging in the management of pericardial disease. Circ Cardiovasc Imaging. 2010;3:333–43. https://doi.org/10.1161/CIRCIMAGING.109.921791.

    Article  PubMed  Google Scholar 

  28. • Cosyns B, Plein S, Nihoyanopoulos P, Smiseth O, Achenbach S, Andrade MJ, et al. European Association of Cardiovascular Imaging (EACVI) position paper: multimodality imaging in pericardial disease. Eur Heart J Cardiovasc Imaging. 2015;16:12–31. https://doi.org/10.1093/ehjci/jeu128. This study provides extensive data on diagnosing pericardial diseases using multimodality imaging.

    Article  PubMed  Google Scholar 

  29. Jeung M-Y, Gasser B, Gangi A, Bogorin A, Charneau D, Wihlm JM, et al. Imaging of cystic masses of the mediastinum. RadioGraphics. 2002;22:S79–93. https://doi.org/10.1148/radiographics.22.suppl_1.g02oc09s79.

    Article  PubMed  Google Scholar 

  30. Maisch B, Seferović PM, Ristić AD, Erbel R, Rienmüller R, Adler Y, et al. Guidelines on the diagnosis and management of pericardial diseases: executive summary. The Task Force on the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology. Eur Heart J. 2004;25:587–610. https://doi.org/10.1016/j.ehj.2004.02.002.

    Article  PubMed  Google Scholar 

  31. Kruger SR, Michaud J, Cannom DS. Spontaneous resolution of a pericardial cyst. Am Heart J. 1985;109:1390–1. https://doi.org/10.1016/0002-8703(85)90372-2.

    Article  CAS  PubMed  Google Scholar 

  32. Butz T, Faber L, Langer C, Wiemer M, Horstkotte D, Piper C. Echocardiography-guided percutaneous aspiration of a large pericardial cyst. Circulation. 2007;116:e505–7. https://doi.org/10.1161/CIRCULATIONAHA.107.711903.

    Article  PubMed  Google Scholar 

  33. Kinoshita Y, Shimada T, Murakami Y, Sano K, Tanabe K, Ishinaga Y, et al. Ethanol sclerosis can be a safe and useful treatment for pericardial cyst. Clin Cardiol. 1996;19:833–5. https://doi.org/10.1002/clc.4960191015.

    Article  CAS  PubMed  Google Scholar 

  34. Maisch B. Alcohol ablation of pericardial cysts under pericardioscopical control. Heart Fail Rev. 2013;18:361–5. https://doi.org/10.1007/s10741-013-9383-x.

    Article  PubMed  Google Scholar 

  35. Matono R, Shoji F, Yano T, Maehara Y. Surgical resection of a giant pericardial cyst showing a rapidly growing feature. Interact Cardiovasc Thorac Surg. 2010;10:1056–8. https://doi.org/10.1510/icvts.2009.231456.

    Article  PubMed  Google Scholar 

  36. Abad C, Rey A, Feijóo J, Gonzalez G, Martín-Suarez J. Pericardial cyst surgical resection in two symptomatic cases. J Cardiovasc Surg (Torino). 1996;37(2):199–202.

  37. Cangemi V, Volpino P, Gualdi G, et al. Pericardial cysts of the mediastinum. J Cardiovasc Surg (Torino). 1999;40(6):909–13.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Allan L. Klein.

Ethics declarations

Conflict of Interest

Allan L. Klein has received research grant support from Kiniksa, advisory board SOBI. Mohamed Khayata, Saqer Alkharabsheh, and Nishant P. Shah declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Pericardial Disease

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Khayata, M., Alkharabsheh, S., Shah, N.P. et al. Pericardial Cysts: a Contemporary Comprehensive Review. Curr Cardiol Rep 21, 64 (2019). https://doi.org/10.1007/s11886-019-1153-5

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11886-019-1153-5

Keywords

Navigation