Abstract
The development of transcatheter valve implantations (TAVI) has induced profound changes in the treatment of valvular heart disease over the past decade. At the same time, due to excellent clinical results, bioprostheses continuously outperformed mechanical prostheses. The increasing number of elderly patients has led to numerous patients presenting with deteriorated bioprostheses needing reoperation. In selected high-risk patients or patients with unreasonable surgical risk, valve-in-valve TAVI has advanced to a viable alternative to conventional redo surgery. High procedural success, good hemodynamics and acceptable clinical results were reported up until now. Valve-in-valve TAVI seems to be safe and effective in treatment of deteriorated valve prostheses in high-risk patients. The valve-in-valve concept presents the next step toward an individual treatment strategy for patients at prohibitive risk for conventional surgery. Present studies were reviewed with special concern to patient selection, prosthesis assessment, device selection, clinical outcome and technical challenging aspects as well.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Wilbring M, Alexiou K, Tugtekin SM, et al. Transapical transcatheter valve-in-valve implantation for deteriorated mitral valve bioprostheses. Ann Thorac Surg. 2012. doi:10.1016/j.athoracsur.2012.08.004. This article gives detailed information about technical aspects of transapical mitral valve-in-valve TAVI.
Cribier A, Eltchaninoff H, Bash A, et al. Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description. Circulation. 2002;106:3006–8.
Gurvitch R, Cheung A, Ye J, et al. Transcatheter valve-in-valve implantation for failed surgical bioprosthetic valves. J Am Coll Cardiol. 2011;58:2196–209.
Seiffert M, Conradi L, Baldus S, et al. Transcatheter mitral valve-in-valve implantation in patients with degenerated bioprostheses. JACC Cardiovasc Interv. 2012;5:341–9.
Piazza N, Bleiziffer S, Brockmann G, et al. Transcatheter aortic valve implantation for failing surgical aortic bioprosthetic valve: from concept to clinical application and evaluation (part 1). JACC Cardiovasc Interv. 2011;4:721–32. This article provides detailed information about failing mechanisms of prosthetic valves and gives detailed report of several cases.
Jones JM, O'kane H, Gladstone DJ, et al. Repeat heart valve surgery: risk factors for operative mortality. J Thorac Cardiovasc Surg. 2001;122:913–8.
Maganti M, Rao V, Armstrong S, et al. Redo valvular surgery in elderly patients. Ann Thorac Surg. 2009;87:521–5.
Walther T, Falk V, Dewey T, et al. Valve-in-a-valve concept for transcatheter minimally invasive repeat xenograft implantation. J Am Coll Cardiol. 2007;50:56–60.
Kempfert J, Van Linden A, Linke A, et al. Transapical off-pump valve-in-valve implantation in patients with degenerated aortic xenografts. Ann Thorac Surg. 2010;89:1934–41.
•• Eggebrecht H, Schäfer U, Treede H, et al. Valve-in-valve transcatheter aortic valve implantation for degenerated bioprosthetic heart valves. JACC Cardiovasc Interv. 2011;4:1218–27. This well-designed study provides essential information and technical insights about valve-in-valve TAVI.
Wilbring M, Sill B, Tugtekin SM, et al. Transcatheter valve-in-valve implantation for deteriorated aortic bioprosthesis: initial clinical results and follow-up in a series of high-risk patients. Ann ThoracSurg. 2012;93:734–41.
Kempfert J, Blumenstein JM, Borger MA, et al. Minimally invasive off-pump valve-in-a-valve implantation: the atrial transcatheter approach for re-operative mitral valve replacement. Eur Heart J. 2008;29:2382–7.
Cheung A, Webb JG, Wong DR, et al. Transapical transcatheter mitral valve-in-valve implantation in a human. Ann Thorac Surg. 2009;87:e18–20.
Seiffert M, Franzen O, Conradi L, et al. Series of transcatheter valve-in-valve implantations in high-risk patients with degenerated bioprostheses in aortic and mitral position. Catheter Cardiovasc Interv. 2010;76:608–15.
Cheung AW, Gurvitch R, Ye J, et al. Transcatheter transapical mitral valve-in-valve implantations for a failed bioprosthesis: a case series. J Thorac Cardiovasc Surg. 2011;141:711–5.
Kempfert J, Blumenstein J, Chu MW, et al. Minimally invasive off-pump valve-in-a-ring implantation: the atrial transcatheter approach for re-operative mitral valve replacement after failed repair. Eur J Cardiothorac Surg. 2009;35:965–9.
Ghazy T, Kappert U, Ouda A, et al. A question of clinical reliability: observed versus EuroSCORE-predicted mortalityafter aortic valve replacement. J Heart Valve Dis. 2010;19:16–20.
• Walther T, Schuler G, Borger MA, et al. Transapical aortic valve implantation in 100 consecutive patients: comparison to propensity-matched conventional aortic valve replacement. Eur Heart J. 2010;31:1398–403. Well-designed study providing baseline clinical results of the TAVI-procedure in comparison with conventional aortic valve replacement.
Conradi L, Seiffert M, Treede H, et al. Transcatheter aortic valve implantation versus surgical aortic valve replacement: a propensity score analysis in patients at high surgical risk. J Thorac Cardiovasc Surg. 2012;143:64–71.
Webb JG, Lichtenstein S. Transcatheter percutaneous and transapical aortic valve replacement. Semin Thorac Cardiovasc Surg. 2007;19:304–10.
Kempfert J, Van Linden A, Linke A, et al. Transapical aortic valve implantation: therapy of choice for patients with aortic stenosis and porcelain aorta? Ann Thorac Surg. Nov. 2010;90:1457–61.
Christakis GT, Buth KJ, Goldman BS, et al. Inaccurate and misleading valve sizing: a proposed standard for valve size nomenclature. Ann Thorac Surg. 1998;66:1198–203.
Shibata T, Inoue K, Ikuta T, et al. Which valve and which size should we use in the valve-on-valve technique for re-do mitral valve surgery? Interact Cardiovasc Thorac Surg. 2009;8:206–10.
Nietlispach F, Wijesinghe N, Wood D, et al. Current balloon-expandable transcatheter heart valve and delivery systems. Catheter Cardiovasc Interv. 2010;75:295–300.
Azadani AN, Jaussaud N, Matthews PB, et al. Aortic valve-in-valve implantation: impact of transcatheter- bioprosthesis size mismatch. J Heart Valve Dis. 2009;18:367–73.
Khawaja MZ, Haworth P, Ghuran A, et al. Transcatheter aortic valve implantation for stenosed and regurgitant aortic valve bioprostheses CoreValve for failed bioprosthetic aortic valve replacements. J Am Coll Cardiol. 2010;55:97–101.
Hasan BS, McElhinney DB, Brown DW, et al. Short-term performance of the transcatheter Melody valve in high-pressure hemodynamic environments in the pulmonary and systemic circulations. Circ Cardiovasc Interv. 2011;4:615–20.
Kempfert J, Blumenstein J, Chu MW, et al. Minimally invasive off-pump valve-in-a-ring implantation: the atrial transcatheter approach for re-operative mitral valve replacement after failed repair. Eur J Cardiothorac Surg. 2009;35:965–9. discussion 969.
• Kondo N, Shuto T, McGarvey JR, et al. Melody valve-in-ring procedure for mitral valve replacement: feasibility in four annuloplasty types. Ann Thorac Surg. 2012;93:783–8. This article gives an idea of developing fields in valve-in-valve TAVI.
Cerillo AG, Chiaramonti F, Murzi M, et al. Transcatheter valve in valve implantation for failed mitral and tricuspid bioprosthesis. Catheter Cardiovasc Interv. 2011;78:987–95.
Jux C, Akintuerk H, Schranz D. Two melodies in concert: Transcatheter double-valve replacement. Catheter Cardiovasc Interv. 2011 Nov 22.
Riede FT, Dähnert I. Implantation of a Melody® valve in triscuspid position. Catheter Cardiovasc Interv. 2012;80:474–6.
Faza N, Kenny D, Kavinsky C, et al. Single center comparative outcomes of the edwardssapien and medtronic melody transcatheter heart valves in the pulmonary position. Catheter Cardiovasc Interv. 2012 Sep 25.
Kapetanakis EI, MacCarthy P, Monaghan M, Wendler O. Trans-apical aortic valve implantation in a patient with stentless valve degeneration. Eur J Cardiothorac Surg. 2011;39(6):1051–3.
Bagur R, Rodés-Cabau J, De Larochellière R, et al. Transfemoral aortic valve-in-valve implantation with a balloon-expandable valve for the treatment of stentless xenograft severe aortic regurgitation. JACC Cardiovasc Interv. 2011;4:1248–9.
Finch J, Roussin I, Pepper J. Failing stentless aortic valves: redo aortic root replacement or valve in a valve? Eur J Cardiothorac Surg. 2012 Aug 29.
Seiffert M, Baldus S, Conradi L, et al. Simultaneous transcatheter aortic and mitral valve-in-valve implantation in a patient with degenerated bioprostheses and high surgical risk. Thorac Cardiovasc Surg. 2011;59:490–2.
Pasic M, Unbehaun A, Dreysse S, et al. Transapical aortic valve implantation after previous aortic valve replacement: clinical proof of the "valve-in-valve" concept. J Thorac Cardiovasc Surg. 2011;142:270–7.
Webb JG, Wood DA, Ye J, et al. Transcatheter valve-in-valve implantation for failed bioprosthetic heart valves. Circulation. 2010;121:1848–57.
Gotzmann M, Mügge A, Bojara W. Transcatheter aortic valve implantation for treatment of patients with degenerated aortic bioprostheses–valve-in-valve technique. Catheter Cardiovasc Interv. 2010;76:1000–6.
Wenaweser P, Pilgrim T, Windecker S, et al. Transapical valve-in-valve implantation for regurgitant stented aortic bioprostheses. J Heart Valve Dis. 2012;21:344–9.
Piazza N, Bleiziffer S, Brockmann G, et al. Transcatheter aortic valve implantation for failing surgical aortic bioprosthetic valve: from concept to clinical application and evaluation (part 2). JACC Cardiovasc Interv. 2011;4:733–42.
Roberts PA, Boudjemline Y, Cheatham JP, et al. Percutaneous tricuspid valve replacement in congenital and acquired heart disease. J Am Coll Cardiol. 2011;58:117–22.
• Danny Dvir, MD, on behalf of the Global Valve-in-Valve Registry investigators. Transcatheter Aortic-Valve Implantation for the Treatment of Degenerative Bioprosthetic Surgical Valves: Results from the Global Valve-in-Valve Registry. Presented at EuroPCR 2012; www.valveinvalve.com. This is the largest collection of valve-in-valve TAVI up to now
McElhinney DB, Hellenbrand WE, Zahn EM, et al. Short- and medium-term outcomes after transcatheter pulmonary valve placement in the expanded multicenter US melody valve trial. Circulation. 2010;122:507–16.
Michelena HI, Alli O, Cabalka AK, Rihal CS. Successful percutaneous transvenous antegrade mitral valve-in-valve implantation. Catheter Cardiovasc Interv. 2012. doi:10.1002/ccd.24423.
Disclosure
No potential conflicts of interest relevant to this article were reported.
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is part of the Topical Collection on Valvular Heart Disease
Rights and permissions
About this article
Cite this article
Wilbring, M., Alexiou, K., Tugtekin, SM. et al. Transcatheter Valve-in-Valve Therapies: Patient Selection, Prosthesis Assessment and Selection, Results, and Future Directions. Curr Cardiol Rep 15, 341 (2013). https://doi.org/10.1007/s11886-012-0341-3
Published:
DOI: https://doi.org/10.1007/s11886-012-0341-3