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Chronic Kidney Disease as a Coronary Artery Disease Risk Equivalent

  • Ischemic Heart Disease (D Mukherjee, Section Editor)
  • Published:
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Abstract

Chronic kidney disease (CKD) is associated with accelerated cardiovascular disease (CVD) risk and a higher CVD event rate. Substantial data from prospective cohort studies support the concept that dialysis patients as well as those with advanced stage (stages 3–5) CKD are associated with an increased risk for all-cause and cardiovascular mortality. The risk for coronary artery disease (CAD) increases exponentially with declining kidney function, i.e., stage 3 or higher CKD. Indeed, CVD accounts for more than 50 % of deaths in patients with CKD. CKD patients are more likely to die of CVD than to progress to end stage kidney disease. This increase in CV risk is commonly attributed to co-existence of numerous traditional and nontraditional risk factors for the development of CVD that frequently accompany reduced kidney function. Therefore, CKD itself is now considered an independent CVD risk factor and a coronary artery disease (CAD) equivalent for all-cause mortality. All patients at risk for CAD should be evaluated for kidney disease. Treatments used for management of established CAD might have similar benefits for patients with concomitant CKD.

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Disclosure

Conflicts of interest: A. Briasoulis: none; G.L. Bakris: has been a consultant for Abbott, Takeda, Novartis, Medtronic, Relapysa; has received grant support from Takeda, Forest Laboratories.

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Authors and Affiliations

  1. ASH Comprehensive Hypertension Center, Department of Medicine, The University of Chicago Medicine, 5841 S. Maryland Ave MC 1027, Chicago, IL, 60637, USA

    Alexandrios Briasoulis & George L. Bakris

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  1. Alexandrios Briasoulis
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  2. George L. Bakris
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Correspondence to George L. Bakris.

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This article is part of the Topical Collection on Ischemic Heart Disease

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Briasoulis, A., Bakris, G.L. Chronic Kidney Disease as a Coronary Artery Disease Risk Equivalent. Curr Cardiol Rep 15, 340 (2013). https://doi.org/10.1007/s11886-012-0340-4

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  • DOI: https://doi.org/10.1007/s11886-012-0340-4

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