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Biomarkers for Bladder Pain Syndrome/Interstitial Cystitis

  • BPS/Interstitial Cystitis (D Castro-Diaz and Y Igawa, Section Editors)
  • Published:
Current Bladder Dysfunction Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

In this manuscript, the literature published in the past 5 years about BPS/IC biomarkers was reviewed. Topics include BPS/IC biomarkers, the classical BPS/IC diagnostic, clinical outcomes as a new concept of BPS/IC phenotyping biomarkers, BPS/IC urinary biomarkers, BPS/IC bladder tissue biomarkers and BPS/IC biomarkers outside the bladder.

Recent Findings

The importance of patients’ phenotyping and sub-grouping emerged as a way of finding new BPS/IC biomarkers and treatment. Also, the use of non-invasive methodologies and of artificial intelligence approaches has been gaining momentum in BPS/IC biomarkers studies.

Summary

Biomarker research points to the need of following an approach based on a systemic theory instead of a bladder-centred theory. Also, the importance of sample size and the choice of controls to validate BPS/IC biomarkers have been elevated.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Department of Biomedicine, Experimental Biology Unit, Faculty of Medicine of University of Porto, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal

    Ana Charrua & Célia Cruz

  2. Translational NeuroUrology, Instituto de Investigação e Inovação em Saúde - i3S, Universidade do Porto, Porto, Portugal

    Ana Charrua & Célia Cruz

  3. Department of Urology, Centro Hospitalar São João, Porto, Portugal

    Pedro Mendes

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  1. Ana Charrua
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Correspondence to Ana Charrua.

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Charrua, A., Mendes, P. & Cruz, C. Biomarkers for Bladder Pain Syndrome/Interstitial Cystitis. Curr Bladder Dysfunct Rep 16, 12–18 (2021). https://doi.org/10.1007/s11884-020-00626-9

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