References
Lagace TA, Curtis DE, Garuti R, et al.:Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest 2006, 116:2995–3005.
Abifadel M, Varret M, Rabes JP, et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003, 34:154–156.
Cohen J, Pertsemlidis A, Kotowski IK, et al.: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005, 37:161–165.
Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH: Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006, 354:1264–1272.
Chen SN, Ballantyne CM, Gotto AM Jr, et al.: A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol 2005, 45:1611–1619.
Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al.: Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A 2008, 105:11915–11920.
Ridker PM, Danielson E, Fonseca FA, et al.: Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 2009, 373:1175–1182.
Dubuc G, Chamberland A, Wassef H, et al.: Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2004, 24:1454–1459.
Marian AJ: Nature’s genetic gradients and the clinical phenotype. Circ Cardiovasc Genet 2009, 2:537–539.
Zhao Z, Tuakli-Wosornu Y, Lagace TA, et al.: Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. Am J Hum Genet 2006, 79:514–523.
Graham MJ, Lemonidis KM, Whipple CP, et al.: Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res 2007, 48:763–767.
Duff CJ, Scott MJ, Kirby IT, et al.: Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J 2009, 419:577–584.
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Marian, A.J. PCSK9 as a Therapeutic Target in Atherosclerosis. Curr Atheroscler Rep 12, 151–154 (2010). https://doi.org/10.1007/s11883-010-0099-2
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DOI: https://doi.org/10.1007/s11883-010-0099-2