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B Cell Disorders in Children: Part II

  • Pediatric Allergy and Immunology (W Dolen, Section Editor)
  • Published:
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Abstract

Purpose of Review

B cell disorders result in decreased levels or function of immunoglobulins in an individual. Genetic mutations have been reported in a variety of B cell disorders. This review, in follow-up to a previous review, describes some rare B cell disorders as well as their known underlying genetic etiologies.

Recent Findings

Genetic studies identify and permit precise classification of an increasing number of B cell disorders, leading to a greater understanding of B cell development and function.

Summary

The B cell disorders are rare diseases. While clinicians are most familiar with X-linked agammaglobulinemia and so-called common variable immunodeficiency (CVID), there are many causes of hypogammaglobulinemia. Genetic testing provides a specific diagnosis, offers useful information for genetic counseling, and can identify previously unrecognized B cell disorders.

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  1. Department of Pediatrics, Allergy-Immunology and Pediatric Rheumatology Division,, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, USA

    Dixie D. Griffin & William K. Dolen

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Griffin, D.D., Dolen, W.K. B Cell Disorders in Children: Part II. Curr Allergy Asthma Rep 20, 64 (2020). https://doi.org/10.1007/s11882-020-00963-z

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