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New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma

  • Asthma (WJ Calhoun and V Ortega, Section Editors)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

CHI3L1 (also known as YKL-40), a member of “mammalian chitinase-like proteins,” is a serum protein lacking enzymatic activity. Although the protein is highly conserved in mammals, a consensus regarding its role in human pathologies is currently lacking. In an attempt to shed light on the many physiological functions of the protein, specifically with regard to asthma, a comprehensive overview of recent studies is provided.

Recent Findings

In asthma, CHI3L1 is secreted from macrophages and airway epithelial cells through an IL-13 related mechanism. Th2-associated inflammatory responses due to allergen exposure, resulting in airway hyper-responsiveness and smooth muscle contraction, play a role in tissue remodeling.

Summary

The importance of CHI3L1 in initiation and development of asthma is not limited to its involvement in highly orchestrated events of inflammatory cytokines but further research is needed for further elucidation. Levels of the protein are associated with severity for numerous pathologies, including asthma, suggesting limited specificity as a biomarker.

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Authors and Affiliations

  1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Daniel Elieh Ali Komi & Tohid Kazemi

  2. Department of Immunology, International Branch of Aras, Tabriz University of Medical Sciences, Tabriz, Iran

    Daniel Elieh Ali Komi

  3. Student’s Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Daniel Elieh Ali Komi

  4. Tropical Medicine Laboratory Consultancy, Amsterdam, The Netherlands

    Anton Pieter Bussink

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  1. Daniel Elieh Ali Komi
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Correspondence to Anton Pieter Bussink.

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Drs. Elieh Ali Komi, Kazemi, and Bussink declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Asthma

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Komi, D.E.A., Kazemi, T. & Bussink, A.P. New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma. Curr Allergy Asthma Rep 16, 57 (2016). https://doi.org/10.1007/s11882-016-0637-2

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