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An Overview of Integrative Therapies in Asthma Treatment

  • ASTHMA (WJ CALHOUN AND SP PETERS, SECTION EDITORS)
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Abstract

Treatment of asthma lends itself to an integrative medicine approach due to the multifactorial nature of the disease. It is well established that asthma has a neuromuscular component (bronchospasm), an immunological component (inflammation), and a psychological component. This encourages the use of diverse approaches to address all avenues of pathophysiology, aiming for the most effective blend of treatment approaches possible. Integrative medicine is defined by NIH NCCAM (http://nccam.nih.gov) as medicine that blends the use of evidence-based complementary therapies with conventional medicine. Statistics from the 2007 National Health Interview Survey (NHIS), conducted by the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics (NCHS), showed that approximately four out of 10 adults and approximately one in nine children and more than 50 % of children living with chronic illness, including asthma, used complementary therapies in the USA in 2007. Asthma and allergies rank among the top 15 most common medical conditions in which integrative therapies are used in both children and adults. To date, integrative treatment approaches with some evidence for benefit in asthma treatment include the following: nutrition modification, mind-body medicine, physical activity, and certain dietary supplement interventions.

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References

  1. Prevention CfDCa. Asthma in the US 2011 [May]. http://www.cdc.gov/VitalSigns/Asthma/index.html.

  2. Polonikov AV, Ivanov VP, Bogomazov AD, Freidin MB, Illig T, Solodilova MA. Antioxidant defense enzyme genes and asthma susceptibility: gender-specific effects and heterogeneity in gene-gene interactions between pathogenetic variants of the disease. BioMed Res Int. 2014;2014:708903.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Wade A, Chang C. Evaluation and treatment of critical asthma syndrome in children. Clin Rev Allergy Immunol. 2014. doi:10.1007/s12016-014-8408-0

  4. Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. National Health Stat Rep. 2008;12:1–23.

    Google Scholar 

  5. Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Adv Data. 2004;343:1–19.

    PubMed  Google Scholar 

  6. Kemper KJ. Separation or synthesis: a holistic approach to therapeutics. Pediatr Rev/Am Acad Pediatr. 1996;17(8):279–83.

    Article  CAS  Google Scholar 

  7. Maizes V, Rakel D, Niemiec C. Integrative medicine and patient-centered care. Explore. 2009;5(5):277–89.

    Article  PubMed  Google Scholar 

  8. Reznik M, Ozuah PO, Franco K, Cohen R, Motlow F. Use of complementary therapy by adolescents with asthma. Arch Pediatr Adolesc Med. 2002;156(10):1042–4.

    Article  PubMed  Google Scholar 

  9. Cotton S, Luberto CM, Yi MS, Tsevat J. Complementary and alternative medicine behaviors and beliefs in urban adolescents with asthma. J Asthma Off J Assoc Care of Asthma. 2011;48(5):531–8.

    Article  Google Scholar 

  10. Shen J, Oraka E. Complementary and alternative medicine (CAM) use among children with current asthma. Prev Med. 2012;54(1):27–31.

    Article  PubMed  Google Scholar 

  11. Marino LA, Shen J. Characteristics of complementary and alternative medicine use among adults with current asthma, 2006. J Asthma Off J Assoc Care Asthma. 2010;47(5):521–5.

    Article  Google Scholar 

  12. Knoeller GE, Mazurek JM, Moorman JE. Complementary and alternative medicine use among adults with work-related and non-work-related asthma. J Asthma Off J Assoc Care of Asthma. 2012;49(1):107–13.

    Article  Google Scholar 

  13. Ball SD, Kertesz D, Moyer-Mileur LJ. Dietary supplement use is prevalent among children with a chronic illness. J Am Diet Assoc. 2005;105(1):78–84.

    Article  PubMed  Google Scholar 

  14. George M, Birck K, Hufford DJ, Jemmott LS, Weaver TE. Beliefs about asthma and complementary and alternative medicine in low-income inner-city African-American adults. J Gen Intern Med. 2006;21(12):1317–24.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Gilmour J, Harrison C, Cohen MH, Vohra S. Pediatric use of complementary and alternative medicine: legal, ethical, and clinical issues in decision-making. Pediatrics. 2011;128 Suppl 4:S149–54.

    Article  PubMed  Google Scholar 

  16. Adams D, Dagenais S, Clifford T, Baydala L, King WJ, Hervas-Malo M, et al. Complementary and alternative medicine use by pediatric specialty outpatients. Pediatrics. 2013;131(2):225–32.

    Article  PubMed  Google Scholar 

  17. Gilmour J, Harrison C, Asadi L, Cohen MH, Vohra S. Referrals and shared or collaborative care: managing relationships with complementary and alternative medicine practitioners. Pediatrics. 2011;128 Suppl 4:S181–6.

    Article  PubMed  Google Scholar 

  18. American Board of Physician Specialties. Available from: http://www.abpsus.org.

  19. Bell MC, Busse WW. Severe asthma: an expanding and mounting clinical challenge. J Allergy Clin Immunology Practice. 2013;1(2):110–21. quiz 22.

    Article  Google Scholar 

  20. van Rensen EL, Evertse CE, van Schadewijk WA, van Wijngaarden S, Ayre G, Mauad T, et al. Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment. Allergy. 2009;64(1):72–80.

    Article  PubMed  Google Scholar 

  21. Linares Segovia B, Cortes Sandoval G, Amador Licona N, Guizar Mendoza JM, Nunez Lemus E, Rocha Amador DO, et al. Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. BMC Pulm Med. 2014;14(1):111.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM. Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood. Pulm Pharmacol Ther 2014. doi:10.1016/j.pupt.2014.06.001.

  23. Vliagoftis H. Psychological stress and asthma: a new enemy within. Int Arch Allergy Immunol. 2014;164(2):109–11.

    Article  PubMed  Google Scholar 

  24. Eilayyan O, Gogovor A, Mayo N, Ernst P, Ahmed S. Predictors of perceived asthma control among patients managed in primary care clinics. Qual Life Res: Int J Qual Life Asp Treat Care Rehabil. 2014. doi:10.1007/s11136-014-0700-1.

  25. Tapp H, Hebert L, Dulin M. Comparative effectiveness of asthma interventions within a practice based research network. BMC Health Serv Res. 2011;11:188.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Scott HA, Jensen ME, Wood LG. Dietary interventions in asthma. Curr Pharm Des. 2014;20(6):1003–10.

    Article  CAS  PubMed  Google Scholar 

  27. Tognon G, Lissner L, Saebye D, Walker KZ, Heitmann BL. The Mediterranean diet in relation to mortality and CVD: a Danish cohort study. Br J Nutr. 2013;111(1):151–9.

    Article  PubMed  Google Scholar 

  28. Hoevenaar-Blom MP, Nooyens AC, Kromhout D, Spijkerman AM, Beulens JW, van der Schouw YT, et al. Mediterranean style diet and 12-year incidence of cardiovascular diseases: the EPIC-NL cohort study. PLoS One. 2012;7(9):e45458.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Tognon G, Hebestreit A, Lanfer A, Moreno LA, Pala V, Siani A, et al. Mediterranean diet, overweight and body composition in children from eight European countries: cross-sectional and prospective results from the IDEFICS study. Nutr Metab Cardiovasc Dis. 2014;24(2):205–13.

    Article  CAS  PubMed  Google Scholar 

  30. Arvaniti F, Priftis KN, Papadimitriou A, Papadopoulos M, Roma E, Kapsokefalou M, et al. Adherence to the Mediterranean type of diet is associated with lower prevalence of asthma symptoms, among 10–12 years old children: the PANACEA study. Pediatric Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol. 2011;22(3):283–9.

    Article  Google Scholar 

  31. Saadeh D, Salameh P, Baldi I, Raherison C. Diet and allergic diseases among population aged 0 to 18 years: myth or reality? Nutrients. 2013;5(9):3399–423.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Grigoropoulou D, Priftis KN, Yannakoulia M, Papadimitriou A, Anthracopoulos MB, Yfanti K, et al. Urban environment adherence to the Mediterranean diet and prevalence of asthma symptoms among 10- to 12-year-old children: the Physical Activity, Nutrition, and Allergies in Children Examined in Athens study. Allergy Asthma Proc Off J Reg State Allergy Soc. 2011;32(5):351–8.

    Article  Google Scholar 

  33. Chatzi L, Torrent M, Romieu I, Garcia-Esteban R, Ferrer C, Vioque J, et al. Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax. 2008;63(6):507–13.

    Article  CAS  PubMed  Google Scholar 

  34. Chatzi L, Kogevinas M. Prenatal and childhood Mediterranean diet and the development of asthma and allergies in children. Public Health Nutr. 2009;12(9A):1629–34.

    Article  PubMed  Google Scholar 

  35. Kremmyda LS, Vlachava M, Noakes PS, Diaper ND, Miles EA, Calder PC. Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review. Clin Rev Allerg Immunol. 2011;41(1):36–66.

    Article  CAS  Google Scholar 

  36. Maslova E, Strom M, Oken E, Campos H, Lange C, Gold D, et al. Fish intake during pregnancy and the risk of child asthma and allergic rhinitis—longitudinal evidence from the Danish National Birth Cohort. Br J Nutr. 2013;110(7):1313–25.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  37. Sexton P, Black P, Metcalf P, Wall CR, Ley S, Wu L, et al. Influence of Mediterranean diet on asthma symptoms, lung function, and systemic inflammation: a randomized controlled trial. J Asthma Off J Assoc Care of Asthma. 2013;50(1):75–81.

    Article  Google Scholar 

  38. Barros R, Moreira A, Fonseca J, de Oliveira JF, Delgado L, Castel-Branco MG, et al. Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control. Allergy. 2008;63(7):917–23.

    Article  CAS  PubMed  Google Scholar 

  39. Barros R, Moreira A, Fonseca J, Delgado L, Castel-Branco MG, Haahtela T, et al. Dietary intake of alpha-linolenic acid and low ratio of n-6:n-3 PUFA are associated with decreased exhaled NO and improved asthma control. Br J Nutr. 2011;106(3):441–50.

    Article  CAS  PubMed  Google Scholar 

  40. Huffnagle GB. Increase in dietary fiber dampens allergic responses in the lung. Nat Med. 2014;20(2):120–1.

    Article  CAS  PubMed  Google Scholar 

  41. George M, Topaz M. A systematic review of complementary and alternative medicine for asthma self-management. Nursing Clin North Am. 2013;48(1):53–149.

    Article  Google Scholar 

  42. Arnold E, Clark CE, Lasserson TJ, Wu T. Herbal interventions for chronic asthma in adults and children. Cochrane Database Syst Rev. 2008;1, CD005989.

    PubMed  Google Scholar 

  43. Clark CE, Arnold E, Lasserson TJ, Wu T. Herbal interventions for chronic asthma in adults and children: a systematic review and meta-analysis. Prim Care Respir J: J General Pract Airways Group. 2010;19(4):307–14.

    Article  Google Scholar 

  44. Innis SM, Novak EM, Keller BO. Long chain omega-3 fatty acids: micronutrients in disguise. Prostaglandins Leukot Essent Fat Acids. 2013;88(1):91–5.

    Article  CAS  Google Scholar 

  45. Mozurkewich EL, Klemens C. Omega-3 fatty acids and pregnancy: current implications for practice. Curr Opin Obstet Gynecol. 2012;24(2):72–7.

    Article  PubMed  Google Scholar 

  46. Mickleborough TD, Lindley MR, Ionescu AA, Fly AD. Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest. 2006;129(1):39–49.

    Article  CAS  PubMed  Google Scholar 

  47. D’Auria E, Miraglia Del Giudice M, Barberi S, Mandelli M, Verduci E, Leonardi S, et al. Omega-3 fatty acids and asthma in children. Allergy Asthma Proc Off J Reg State Allergy Soc. 2014;35(3):233–40.

    Article  Google Scholar 

  48. Yates CM, Calder PC, Ed RG. Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease. Pharmacol Ther. 2014;141(3):272–82.

    Article  CAS  PubMed  Google Scholar 

  49. Miles EA, Calder PC. Omega-6 and omega-3 polyunsaturated fatty acids and allergic diseases in infancy and childhood. Curr Pharm Des. 2014;20(6):946–53.

    Article  CAS  PubMed  Google Scholar 

  50. Paul G, Brehm JM, Alcorn JF, Holguin F, Aujla SJ, Celedon JC. Vitamin D and asthma. Am J Respir Crit Care Med. 2012;185(2):124–32.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  51. Holick MF. The vitamin D epidemic and its health consequences. J Nutrition. 2005;135(11):2739S–48S.

    CAS  Google Scholar 

  52. Kennel KA, Drake MT. Vitamin D in the cancer patient. Curr Opin Support Palliat Care. 2013;7(3):272–7.

    PubMed Central  PubMed  Google Scholar 

  53. Gupta A, Bush A, Hawrylowicz C, Saglani S. Vitamin D and asthma in children. Paediatr Respir Rev. 2012;13(4):236–43. quiz 43.

    Article  PubMed  Google Scholar 

  54. Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA J Am Med Assoc. 2014;311(20):2083–91.

    Article  CAS  Google Scholar 

  55. Berraies A, Hamzaoui K, Hamzaoui A. Link between vitamin D and airway remodeling. J Asthma allergy. 2014;7:23–30.

    PubMed Central  PubMed  Google Scholar 

  56. Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM. Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Ann N Y Acad Sci. 2014;1317(1):57–69.

    Article  CAS  PubMed  Google Scholar 

  57. Poon AH, Mahboub B, Hamid Q. Vitamin D deficiency and severe asthma. Pharmacol Ther. 2013;140(2):148–55.

    Article  CAS  PubMed  Google Scholar 

  58. Milan SJ, Hart A, Wilkinson M. Vitamin C for asthma and exercise-induced bronchoconstriction. Cochrane Database Syst Rev. 2013;10, CD010391.

    PubMed  Google Scholar 

  59. Runeson-Broberg R, Norback D. Work-related psychosocial stress as a risk factor for asthma, allergy, and respiratory infections in the Swedish workforce. Psychol Rep. 2014;114(2):377–89.

    Article  PubMed  Google Scholar 

  60. Luberto CM, Yi MS, Tsevat J, Leonard AC, Cotton S. Complementary and alternative medicine use and psychosocial outcomes among urban adolescents with asthma. J Asthma Off J Assoc Care of Asthma. 2012;49(4):409–15.

    Article  Google Scholar 

  61. Maher-Loughnan GP, Mason AA, Macdonald N, Fry L. Controlled trial of hypnosis in the symptomatic treatment of asthma. Br Med J. 1962;2(5301):371–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  62. Ewer TC, Stewart DE. Improvement in bronchial hyper-responsiveness in patients with moderate asthma after treatment with a hypnotic technique: a randomised controlled trial. Br Med J (Clin Res Ed). 1986;293(6555):1129–32.

    Article  CAS  Google Scholar 

  63. Kohen DP, Olness KN, Colwell SO, Heimel A. The use of relaxation-mental imagery (self-hypnosis) in the management of 505 pediatric behavioral encounters. J Dev Behav Pediatr JDBP. 1984;5(1):21–5.

    Article  CAS  Google Scholar 

  64. Anbar RD. Hypnosis in pediatrics: applications at a pediatric pulmonary center. BMC Pediatr. 2002;2:11.

    Article  PubMed Central  PubMed  Google Scholar 

  65. Jon Kabat-Zinn P. Wherever You Go, There you are: mindfulness meditation in everyday life. New York: Hyperion Books; 1994.

  66. Pbert L, Madison JM, Druker S, Olendzki N, Magner R, Reed G, et al. Effect of mindfulness training on asthma quality of life and lung function: a randomised controlled trial. Thorax. 2012;67(9):769–76.

    Article  PubMed  Google Scholar 

  67. Cowie RL, Conley DP, Underwood MF, Reader PG. A randomised controlled trial of the Buteyko technique as an adjunct to conventional management of asthma. Respir Med. 2008;102(5):726–32.

    Article  PubMed  Google Scholar 

  68. Mehl-Madrona L, Kligler B, Silverman S, Lynton H, Merrell W. The impact of acupuncture and craniosacral therapy interventions on clinical outcomes in adults with asthma. Explore. 2007;3(1):28–36.

    Article  PubMed  Google Scholar 

  69. Wechsler ME, Kelley JM, Boyd IO, Dutile S, Marigowda G, Kirsch I, et al. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med. 2011;365(2):119–26.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  70. Vempati R, Bijlani RL, Deepak KK. The efficacy of a comprehensive lifestyle modification programme based on yoga in the management of bronchial asthma: a randomized controlled trial. BMC Pulmonary Medicine. 2009;9:37.

    Article  PubMed Central  PubMed  Google Scholar 

  71. Tahan F, Eke Gungor H, Bicici E. Is yoga training beneficial for exercise-induced bronchoconstriction? Alternative Therapies Health Medicine. 2014;20(2):18–23.

    Google Scholar 

  72. Galantino ML, Galbavy R, Quinn L. Therapeutic effects of yoga for children: a systematic review of the literature. Pediatr Phys Ther Off Publ Sect Pediatr Am Phys Ther Assoc. 2008;20(1):66–80.

    Google Scholar 

  73. Carson KV, Chandratilleke MG, Picot J, Brinn MP, Esterman AJ, Smith BJ. Physical training for asthma. Cochrane Database Syst Rev. 2013;9, CD001116.

    PubMed  Google Scholar 

  74. Beggs S, Foong YC, Le HC, Noor D, Wood-Baker R, Walters JA. Swimming training for asthma in children and adolescents aged 18 years and under. Cochrane Database Syst Rev. 2013;4, CD009607.

    PubMed  Google Scholar 

  75. Wanrooij VH, Willeboordse M, Dompeling E, van de Kant KD. Exercise training in children with asthma: a systematic review. Br J Sports Med. 2014;48(13):1024–31.

    Article  PubMed  Google Scholar 

  76. Walker TJ, Reznik M. In-school asthma management and physical activity: children’s perspectives. J Asthma: Off J Assoc Care of Asthma 2014:1–6. doi:10.3109/02770903.2014.920875.

  77. Corbo GM, Forastiere F, De Sario M, Brunetti L, Bonci E, Bugiani M, et al. Wheeze and asthma in children: associations with body mass index, sports, television viewing, and diet. Epidemiology. 2008;19(5):747–55.

    Article  PubMed  Google Scholar 

  78. Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M, et al. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol. 2014. doi:10.1016/j.jaci.2014.04.018.

  79. Agency USEP. What are the six common air pollutants?

  80. Guarnieri M, Balmes JR. Outdoor air pollution and asthma. Lancet. 2014;383(9928):1581–92.

    Article  CAS  PubMed  Google Scholar 

  81. O’Brien E, Dolinoy DC, Mancuso P. Perinatal bisphenol A exposures increase production of pro-inflammatory mediators in bone marrow-derived mast cells of adult mice. J Immunotoxicol. 2014;11(3):205–12.

    Article  PubMed  Google Scholar 

  82. Nakajima Y, Goldblum RM, Midoro-Horiuti T. Fetal exposure to bisphenol A as a risk factor for the development of childhood asthma: an animal model study. Environ Health Global Access Sci Source. 2012;11:8.

    CAS  Google Scholar 

  83. Donohue KM, Miller RL, Perzanowski MS, Just AC, Hoepner LA, Arunajadai S, et al. Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children. J Allergy Clin Immunol. 2013;131(3):736–42.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  84. Amaral AF. Pesticides and asthma: challenges for epidemiology. Frontiers in Public Health. 2014;2:6.

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

Thanks to Kathleen Kennedy for administrative support.

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Hilary McClafferty declares no conflict of interest.

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  1. Center for Integrative Medicine, University of Arizona, Tucson, AZ, USA

    Hilary McClafferty

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This article is part of the Topical Collection on Asthma

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McClafferty, H. An Overview of Integrative Therapies in Asthma Treatment. Curr Allergy Asthma Rep 14, 464 (2014). https://doi.org/10.1007/s11882-014-0464-2

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