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Allergen Ligands in the Initiation of Allergic Sensitization

  • ALLERGENS (RK BUSH AND JA WOODFOLK, SECTION EDITORS)
  • Published:
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Abstract

As investigations into the innate immune responses that lead to allergic sensitization become better defined, there is a need to determine how allergens could interact with pattern recognition receptors that bind non-proteinaceous moieties. Many important allergens are not covalently bound to lipid or carbohydrate, but have structures belonging to lipid, glycan and glycolipid-binding families. These include ML-domain proteins, lipopolysaccharide-binding/cell permeability-increasing proteins, von Ebner gland lipocalins, salivary lipocalins/major urinary proteins, plant pathogenesis-related proteins PR-5 and -10, uteroglobins, non-specific lipid transfer proteins, large lipid transfer proteins and proteins with chitin and other carbohydrate-binding modules. The binding expected is overviewed with regard to importance of the allergens and their ability to elicit responses proposed from experimental models. The evidence compiled showing that allergens from the same source sensitize for different types of adaptive immune responses supports the concept that individual allergens within these sources have their own distinctive interactions with innate immunity.

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Conflict of Interest

Wayne R. Thomas has received research grant support from the Australian National Health and Medical Research Council.

Human and Animal Rights and Informed Consent

This article does not contain any studies with animal subjects performed by the author. With regard to the author’s research cited in this paper, all procedures were followed in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000 and 2008.

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  1. Centre for Child Health Research, University of Western Australia, Telethon Institute for Child Health Research, 100 Roberts Road, Subiaco, 6008, Western Australia, Australia

    Wayne R. Thomas

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Correspondence to Wayne R. Thomas.

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This article is part of the Topical Collection on Allergens

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Thomas, W.R. Allergen Ligands in the Initiation of Allergic Sensitization. Curr Allergy Asthma Rep 14, 432 (2014). https://doi.org/10.1007/s11882-014-0432-x

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