Skip to main content

Advertisement

Log in

Gastroesophageal Reflux and Rhinosinusitis

  • SINUSITIS (ML KOWALSKI, SECTION EDITOR)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Gastro-esophageal reflux disease (GERD) and chronic rhino-sinusitis (CRS) are prevalent disorders. Coexistence by chance is to be expected in a number of patients. Coexistence due to shared pathogenic mechanisms is controversial. In this paper, we have described the characteristics of GERD and CRS epidemiologically, diagnostically, and pathophysiologically, and reviewed the existing data about a potential role of gastro-esophageal reflux (GER) in the pathogenesis of CRS. A causal link between GERD and CRS has so far not been sufficiently documented. However, some studies do indicate a correlation. Hence, anti-reflux measures should be considered as an option in CRS, particularly in patients where conventional medical and surgical treatment is insufficient.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20. quiz 43. Epub 2006/08/25.

    Article  PubMed  Google Scholar 

  2. Martinez SD, Malagon IB, Garewal HS, Cui H, Fass R. Non-erosive reflux disease (NERD)--acid reflux and symptom patterns. Aliment Pharmacol Ther. 2003;17(4):537–45. Epub 2003/03/08.

    Article  PubMed  CAS  Google Scholar 

  3. Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2005;54(5):710–7. Epub 2005/04/16.

    Article  PubMed  CAS  Google Scholar 

  4. El-Serag HB. Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol. 2007;5(1):17–26. Epub 2006/12/05.

    Article  PubMed  Google Scholar 

  5. Jaspersen D, Kulig M, Labenz J, Leodolter A, Lind T, Meyer-Sabellek W, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study. Aliment Pharmacol Ther. 2003;17(12):1515–20. Epub 2003/06/26.

    Article  PubMed  CAS  Google Scholar 

  6. Tack J, Becher A, Mulligan C, Johnson DA. Systematic review: the burden of disruptive gastro-oesophageal reflux disease on health-related quality of life. Aliment Pharmacol Ther. 2012;35(11):1257–66. Epub 2012/04/11.

    Article  PubMed  CAS  Google Scholar 

  7. Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agreus L, Jablonowski H, et al. Impact of gastroesophageal reflux disease on work absenteeism, presenteeism and productivity in daily life: a European observational study. Health Qual Life Outcomes. 2009;7:90. Epub 2009/10/20.

    Article  PubMed  Google Scholar 

  8. Wahlqvist P, Karlsson M, Johnson D, Carlsson J, Bolge SC, Wallander MA. Relationship between symptom load of gastro-oesophageal reflux disease and health-related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort. Aliment Pharmacol Ther. 2008;27(10):960–70. Epub 2008/03/05.

    Article  PubMed  CAS  Google Scholar 

  9. Nwokediuko SC. Current trends in the management of gastroesophageal reflux disease: a review. ISRN Gastroenterol. 2012;2012:391631. Epub 2012/07/31.

    PubMed  Google Scholar 

  10. Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166(9):965–71. Epub 2006/05/10.

    Article  PubMed  Google Scholar 

  11. Terry P, Lagergren J, Wolk A, Nyren O. Reflux-inducing dietary factors and risk of adenocarcinoma of the esophagus and gastric cardia. Nutr Cancer. 2000;38(2):186–91. Epub 2001/08/30.

    Article  PubMed  CAS  Google Scholar 

  12. Thompson OM, Beresford SA, Kirk EA, Bronner MP, Vaughan TL. Serum leptin and adiponectin levels and risk of Barrett's esophagus and intestinal metaplasia of the gastroesophageal junction. Obesity. 2010;18(11):2204–11. Epub 2010/01/30.

    Article  PubMed  CAS  Google Scholar 

  13. Shaw MJ, Talley NJ, Beebe TJ, Rockwood T, Carlsson R, Adlis S, et al. Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol. 2001;96(1):52–7. Epub 2001/02/24.

    Article  PubMed  CAS  Google Scholar 

  14. Jones R, Junghard O, Dent J, Vakil N, Halling K, Wernersson B, et al. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther. 2009;30(10):1030–8. Epub 2009/09/10.

    Article  PubMed  CAS  Google Scholar 

  15. Jonasson C, Moum B, Bang C, Andersen KR, Hatlebakk JG. Randomised clinical trial: a comparison between a GerdQ-based algorithm and an endoscopy-based approach for the diagnosis and initial treatment of GERD. Aliment Pharmacol Ther. 2012;35(11):1290–300. Epub 2012/04/19.

    Article  PubMed  CAS  Google Scholar 

  16. Everett CF, Morice AH. Clinical history in gastroesophageal cough. Respir Med. 2007;101(2):345–8. Epub 2006/06/22.

    Article  PubMed  Google Scholar 

  17. Dibaise JK, Sharma VK. Does gastroesophageal reflux contribute to the development of chronic sinusitis? A review of the evidence. Dis Esophagus. 2006;19(6):419–24. Epub 2006/10/31.

    Article  PubMed  CAS  Google Scholar 

  18. Tutuian R, Castell DO. Review article: complete gastro-oesophageal reflux monitoring - combined pH and impedance. Aliment Pharmacol Ther. 2006;24 Suppl 2:27–37. Epub 2006/08/31.

    Article  PubMed  Google Scholar 

  19. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012:50 Suppl.23:1–298. Epub 2012/07/07.

  20. Tasker A, Dettmar PW, Panetti M, Koufman JA, P Birchall J, Koufman JA.. Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope. 2002;112(11):1930–4. Epub 2002/11/20.

    Article  PubMed  Google Scholar 

  21. O'Reilly RC, He Z, Bloedon E, Papsin B, Lundy L, Bolling L, et al. The role of extraesophageal reflux in otitis media in infants and children. Laryngoscope. 2008;118(7 Part 2 Suppl 116):1–9. Epub 2008/07/18.

    Article  PubMed  Google Scholar 

  22. Green BT, Broughton WA, O'Connor JB. Marked improvement in nocturnal gastroesophageal reflux in a large cohort of patients with obstructive sleep apnea treated with continuous positive airway pressure. Arch Intern Med. 2003;163(1):41–5. Epub 2003/01/14.

    Article  PubMed  Google Scholar 

  23. Irwin RS. Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl):80S–94S. Epub 2006/01/24.

    Article  PubMed  Google Scholar 

  24. Gahbauer M, Keane P. Chronic cough: Stepwise application in primary care practice of the ACCP guidelines for diagnosis and management of cough. J Am Acad Nurse Pract. 2009;21(8):409–16. Epub 2009/08/20.

    Article  PubMed  Google Scholar 

  25. el-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology. 1997;113(3):755–60. Epub 1997/09/01.

    Article  PubMed  CAS  Google Scholar 

  26. Carr MM, Poje CP, Ehrig D, Brodsky LS. Incidence of reflux in young children undergoing adenoidectomy. Laryngoscope. 2001;111(12):2170–2. Epub 2002/01/22.

    Article  PubMed  CAS  Google Scholar 

  27. Keles B, Ozturk K, Arbag H, Gunel E, Ozer B. Frequency of pharyngeal reflux in children with adenoid hyperplasia. Int J Pediatr Otorhinolaryngol. 2005;69(8):1103–7. Epub 2005/07/12.

    Article  PubMed  Google Scholar 

  28. Bohmer CJ, Klinkenberg-Knol EC, Niezen-de Boer MC, Meuwissen PR, Meuwissen SG. Dental erosions and gastro-oesophageal reflux disease in institutionalized intellectually disabled individuals. Oral Dis. 1997;3(4):272–5. Epub 1998/06/27.

    Article  PubMed  CAS  Google Scholar 

  29. Loehrl TA, Smith TL. Chronic sinusitis and gastroesophageal reflux: are they related? Curr Opin Otolaryngol Head Neck Surg. 2004;12(1):18–20. Epub 2004/01/09.

    Article  PubMed  Google Scholar 

  30. DiBaise JK, Huerter JV, Quigley EM. Sinusitis and gastroesophageal reflux disease. Ann Intern Med. 1998;129(12):1078. Epub 1998/12/29.

    PubMed  CAS  Google Scholar 

  31. Chambers DW, Davis WE, Cook PR, Nishioka GJ, Rudman DT. Long-term outcome analysis of functional endoscopic sinus surgery: correlation of symptoms with endoscopic examination findings and potential prognostic variables. Laryngoscope. 1997;107(4):504–10. Epub 1997/04/01.

    Article  PubMed  CAS  Google Scholar 

  32. Loehrl TA, Samuels TL, Poetker DM, Toohill RJ, Blumin JH, Johnston N. The role of extraesophageal reflux in medically and surgically refractory rhinosinusitis. Laryngoscope. 2012;122(7):1425–30. Epub 2012/04/28.

    Article  PubMed  Google Scholar 

  33. Loehrl TA. Sinonasal problems and reflux. Facial Plast Surg Clin North Am. 2012;20(1):83–6. Epub 2011/11/22.

    Article  PubMed  Google Scholar 

  34. Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg. 2000;126(7):831–6. Epub 2000/07/11.

    PubMed  CAS  Google Scholar 

  35. Bothwell MR, Parsons DS, Talbot A, Barbero GJ, Wilder B. Outcome of reflux therapy on pediatric chronic sinusitis. Otolaryngol Head Neck Surg. 1999;121(3):255–62. Epub 1999/09/03.

    Article  PubMed  CAS  Google Scholar 

  36. Katle EJ, Hart H, Kjaergaard T, Kvaloy JT, Steinsvag SK. Nose- and sinus-related quality of life and GERD. Eur Arch Otorhinolaryngol. 2012;269(1):121–5. Epub 2011/06/28.

    Article  PubMed  Google Scholar 

  37. Hanna BC, Wormald PJ. Gastroesophageal reflux and chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2012;20(1):15–8. Epub 2011/12/14.

    Article  PubMed  Google Scholar 

  38. DelGaudio JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope. 2005;115(6):946–57. Epub 2005/06/04.

    Article  PubMed  Google Scholar 

  39. Ozmen S, Yucel OT, Sinici I, Ozmen OA, Suslu AE, Ogretmenoglu O, et al. Nasal pepsin assay and pH monitoring in chronic rhinosinusitis. Laryngoscope. 2008;118(5):890–4. Epub 2008/06/04.

    Article  PubMed  Google Scholar 

  40. Ozdek A, Cirak MY, Samim E, Bayiz U, Safak MA, Turet S. A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report. Laryngoscope. 2003;113(4):679–82. Epub 2003/04/03.

    Article  PubMed  Google Scholar 

  41. Dinis PB, Subtil J. Helicobacter pylori and laryngopharyngeal reflux in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2006;134(1):67–72. Epub 2006/01/10.

    Article  PubMed  Google Scholar 

  42. Wong IW, Rees G, Greiff L, Myers JC, Jamieson GG, Wormald PJ. Gastroesophageal reflux disease and chronic sinusitis: in search of an esophageal-nasal reflex. Am J Rhinol Allergy. 2010;24(4):255–9. Epub 2010/09/08.

    Article  PubMed  Google Scholar 

  43. DiBaise JK, Olusola BF, Huerter JV, Quigley EM. Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial. Am J Gastroenterol. 2002;97(4):843–50. Epub 2002/05/11.

    Article  PubMed  Google Scholar 

  44. Flook EP, Kumar BN. Is there evidence to link acid reflux with chronic sinusitis or any nasal symptoms? A review of the evidence. Rhinology. 2011:49(1):11–6. Epub 2011/04/07.

    Google Scholar 

  45. Megale SR, Scanavini AB, Andrade EC, Fernandes MI, Anselmo-Lima WT. Gastroesophageal reflux disease: its importance in ear, nose, and throat practice. Int J Pediatr Otorhinolaryngol. 2006;70(1):81–8. Epub 2005/07/06.

    Article  PubMed  Google Scholar 

  46. Vaezi MF, Hagaman DD, Slaughter JC, Tanner SB, Duncavage JA, Allocco CT, et al. Proton pump inhibitor therapy improves symptoms in postnasal drainage. Gastroenterology. 2010;139(6):1887–93. e1; quiz e11. Epub 2010/08/31.

    Article  PubMed  CAS  Google Scholar 

Download references

Disclosure

No potential conflicts of interest relevant to this article were reported.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Elin-Johanne Katle.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Katle, EJ., Hatlebakk, J.G. & Steinsvåg, S. Gastroesophageal Reflux and Rhinosinusitis. Curr Allergy Asthma Rep 13, 218–223 (2013). https://doi.org/10.1007/s11882-013-0340-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11882-013-0340-5

Keywords

Navigation