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Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

  • Basic and Applied Science (M Frieri, Section Editor)
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Abstract

The purpose of this review article is to highlight articles and new research regarding the link between NF-ĸB and several cancers. This review presents the most up-to-date NF-ĸB research and how it links this important transcription factor with hematology and oncology. It was written by conducting a thorough search of Pubmed as well as several journals such as Cancer, Nature, Science, Cell and those of one of the authors. The articles relating to the link between NF-ĸB and cancer were used to write this review. The results of this study clarified that there is a critical link between NF-ĸB and cancer. NF-ĸB has often been implicated in a variety of different diseases and it plays a variety of roles in cell survival, differentiation, and proliferation of cells. In cancer, NF-ĸB plays a pivotal role by facilitating oncogenesis as well as metastasis. A thorough understanding of NF-ĸB and its role in cancer can lead to future studies and drug development which could provide a novel option in the treatment of this disease.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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  1. 2454 6th Ave, East Meadow, NY, 11554, USA

    Adeel Zubair

  2. Division of Allergy Immunology, Department of Medicine and NSLIJ Health Care Systems, Nassau University Medical Center, 2201Hempstead Turnpike, East Meadow, NY, 11554, USA

    Marianne Frieri

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Zubair, A., Frieri, M. Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer. Curr Allergy Asthma Rep 13, 44–49 (2013). https://doi.org/10.1007/s11882-012-0300-5

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