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ENT manifestations of gastroesophageal reflux

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Abstract

Gastroesophageal reflux (GER) has been associated with a variety of supraesophageal symptoms or diseases, including chronic cough, laryngeal disorders, rhinosinusitis, otitis media, and oral cavity lesions. In this article, we review the relationship between GER and ear, nose, and throat (ENT) symptoms. Data in the published literature are frequently conflicting. Only a few studies are controlled, and an evidence-based approach provides weak support for a causal association between GER and ENT manifestations. The GER diagnostic method should be standardized utilizing new parameters, and the definition and diagnostic accuracy of ENT pathologies also must be better specified. A firm connection remains controversial, and further randomized trials are needed.

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References and Recommended Reading

  1. Friedman M, Friedman M, Schalch P, et al.: Wireless upper esophageal monitoring for laryngopharyngeal reflux (LPR). Otolaryngol Head Neck Surg 2007, 137:471–476.

    Article  PubMed  Google Scholar 

  2. Caruso G, Passàli FM: ENT manifestations of gastrooesophageal reflux in children. Acta Otorhinolaryng Ital 2006, 26:252–255.

    CAS  Google Scholar 

  3. Morice AH: Is reflux cough due to gastroesophageal reflux disease or laryngopharyngeal reflux? Lung 2007, Epub ahead of print.

  4. Groome M, Cotton JP, Borland M, et al.: Prevalence of laryngophyarngeal reflux in a population with gastroesophageal reflux. Laryngoscope 2007, 117:1424–1428.

    Article  PubMed  Google Scholar 

  5. Mesallam TA, Stemple JC, Sobeih TM, et al.: Reflux symptom index versus reflux finding score. Ann Otol Rhinol Laryngol 2007, 116:436–440.

    PubMed  Google Scholar 

  6. Vázquez de la Iglesia F, González SF, de la Cámara Gómez M: Reflujo faringolaríngeo: correlación entre los síntomas y los signos mediante cuestionarios de valoración clínica y fibroendoscópica. Es suficiente para realizar el diagnóstico? Acta Otorrinolaringol Esp 2007, 58:421–425.

    Article  PubMed  Google Scholar 

  7. Hickson C, Simpson CB, Falcon R: Laryngeal pseudosulcus as a predictor of laryngopharyngeal reflux. Laryngoscope 2001, 111:1742–1745.

    Article  PubMed  CAS  Google Scholar 

  8. Belafsky PC, Postma GN, Koufman JA: The association between laryngeal peudosulcus and laryngopharyngeal reflux. Otolaryngol Head Neck Surg 2002, 126:649–652.

    Article  PubMed  Google Scholar 

  9. Joniau S, Bradshaw A, Esterman A, et al.: Reflux and laryngitis: a systematic review. Otolaryngol Head Neck Surg 2007, 136:686–692.

    Article  PubMed  Google Scholar 

  10. Poelmans J, Tack J, Feenstra L: Paroxysmal laryngospasm: a typical but underrecognized supraesophageal manifestation of gastroesophageal reflux? Dig Dis Sci 2004, 49:1868–1874.

    Article  PubMed  Google Scholar 

  11. Manning SC, Inglis AF, Mouzakes J, et al.: Laryngeal anatomic differences in pediatric patients with severe laryngomalacia. Arch Otolaryngol Head Neck Surg 2005, 131:340–343.

    Article  PubMed  Google Scholar 

  12. Poetker DM, Ettema SL, Blumin JH: Association of airway abnormalities and risk factors in 37 subglottic stenosis patients. Otolaryngol Head Neck Surg 2006, 135:434–437.

    Article  PubMed  Google Scholar 

  13. Lin BF, Lee SC, Kao CH, et al.: Subglottic stenosis after thoracotomy: a case report. Acta Anaesthesiol Taiwan 2007, 45:59–62.

    PubMed  Google Scholar 

  14. Qadeer MA, Colabianchi N, Strome M: Gastroesophageal reflux and laryngeal cancer: causation or association? A critical review. Am J Otolaryngol 2006, 27:119–128.

    Article  PubMed  Google Scholar 

  15. Vaezi MF, Qadeer MA, Lopez R: Laryngeal cancer and gastroesophageal reflux disease: a case-control study. Am J Med 2006, 119:768–776.

    Article  PubMed  Google Scholar 

  16. Chandra KM, Harding SM: Therapy insight: treatment of gastroesophageal reflux in adults with chronic cough. Nat Clin Pract Gastroenterol Hepatol 2007, 4:604–613.

    Article  PubMed  Google Scholar 

  17. Ravelli AM, Panarotto MB, Verdoni L, et al.: Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease. Chest 2006, 130:1520–1526.

    Article  PubMed  Google Scholar 

  18. Monteiro VR, Sdepanian VL, Weckx L, et al.: Twenty-four-hour esophageal pH monitoring in children and adolescents with chronic and/or recurrent rhinosinusitis. Braz J Med Biol Res 2005, 38:215–220.

    PubMed  CAS  Google Scholar 

  19. Weber RK, Jaspersen D, Keerl R, et al.: Gastroesophageal reflux disease and chronic sinusitis. Laryngorhinootologie 2004, 83:189–195.

    Article  PubMed  CAS  Google Scholar 

  20. Weaver EM: Association between gastroesophageal reflux and sinusitis, otitis media and laryngeal malignancy: a systematic review of evidence. Am J Med 2003, 115(Suppl 3A):815–895.

    Google Scholar 

  21. Lieu JE, Muthappan PG, Uppaluri R: Association of reflux with otitis media in children. Otolaryngol Head Neck Surg 2005, 133:357–361.

    Article  PubMed  Google Scholar 

  22. Velepic MM, Velepic MS, Starcevic R, et al.: Gastroesophageal reflux and sequelae of chronic tubotympanal disorders in children. Acta Otolaryngol 2004, 124:914–917.

    Article  PubMed  Google Scholar 

  23. Sone M, Yamamuro Y, Hayashi H, et al.: Otitis media in adults as a symptom of gastroesophageal reflux. Otolaryngol Head Neck Surg 2007, 136:19–22.

    Article  PubMed  Google Scholar 

  24. Cebrián-Carretero JL, López-Arcas-Calleja JM: Gastro-esophageal reflux diagnosed by occlusal splint tintion. Med Oral Patol Oral Cir Bucal 2006, 11:E26–E28.

    PubMed  Google Scholar 

  25. Mamede RC, De Mello-Filho FV, Dantas RO: Severe hypertrophy of the base of the tongue in adults. Otolaryngol Head Neck Surg 2004, 131:378–382.

    Article  PubMed  Google Scholar 

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Correspondence to Desiderio Passàli.

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Passàli, D., Caruso, G. & Passàli, F.M. ENT manifestations of gastroesophageal reflux. Curr Allergy Asthma Rep 8, 240–244 (2008). https://doi.org/10.1007/s11882-008-0040-8

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