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Building better mouse models of asthma

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Abstract

Allergic asthma is a complex disease that has been modeled extensively in small rodents. Airway eosinophilia and changes in lung function have been documented using a variety of protocols. However, recent efforts have improved these models by trying to replicate the structural remodeling that occurs in the lung as a consequence of chronic allergen-driven inflammation. This review documents the recent developments in protocols and systems designed to examine pathways leading to allergen-induced airway remodeling.

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Authors and Affiliations

  1. Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, SW7 2AZ, England

    Clare M. Lloyd

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  1. Clare M. Lloyd
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Correspondence to Clare M. Lloyd.

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Lloyd, C.M. Building better mouse models of asthma. Curr Allergy Asthma Rep 7, 231–236 (2007). https://doi.org/10.1007/s11882-007-0077-0

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  • DOI: https://doi.org/10.1007/s11882-007-0077-0

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