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Esthesioneuroblastoma

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Opinion statement

Esthesioneuroblastoma is a rare tumor for which the published literature does not provide an evidence-based consensus treatment approach. Multimodality therapy including a combination of surgery and radiation appears to provide the best disease-free and overall survival. Surgical resection should proceed through a craniofacial approach if possible. The role of chemotherapy in the initial treatment paradigm is less clear. Chemotherapy should not be used as single-modality therapy for initial treatment but may provide additional benefit when used in combination with radiation and surgery, particularly in advanced-stage disease. Combination chemotherapy should be considered as initial therapy for unresectable tumors and metastatic disease, and as salvage therapy in disease recurrence.

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Authors and Affiliations

  1. Section of Hematology and Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, 27157, Winston-Salem, NC, USA

    Heidi D. Klepin (MD)

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  1. Heidi D. Klepin
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  2. Kevin P. McMullen
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  3. Glenn J. Lesser
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Klepin, H.D., McMullen, K.P. & Lesser, G.J. Esthesioneuroblastoma. Curr. Treat. Options in Oncol. 6, 509–518 (2005). https://doi.org/10.1007/s11864-005-0029-7

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