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The levels of advanced oxidation protein products in patients with obstructive sleep apnea syndrome

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Abstract

Background

Obstructive sleep apnea syndrome (OSAS) is characterized by repeated episodes of complete or partial obstructions of the upper airway during sleep, frequently followed by transient hypoxemia. Advanced oxidation protein products (AOPP) are a family of oxidized protein products, and oxidative stress has a substantial role in the morbidity of OSAS.

Aims

The aim of this study was to investigate the serum levels of advanced oxidation protein products (AOPP) as a marker of oxidative stress, and their correlation with polysomnographic parameters in patients with obstructive sleep apnea syndrome (OSAS). Additionally, we investigated the effect of positive airway pressure (PAP) treatment on serum AOPP values and compared the levels before and after the treatment.

Methods

The study enrolled a total of 125 subjects including 59 patients with severe OSAS, 34 patients with moderate OSAS, 32 patients with mild OSAS, and 40 healthy controls. Mean AOPP values were compared between OSAS groups and control groups. Correlations between AOPP and polysomnographic parameters were investigated. Mean AOPP values before and after 6-month PAP therapy were compared.

Results

Significantly elevated AOPP levels were found in severe and moderate OSAS groups in comparison with mild OSAS and control groups. AOPP was directly correlated with apnea-hypopnea index, percentage of total time spent with oxygen saturation below 90%, oxygen desaturation index, maximum obstructive apnea duration, arousal index, and number of obstructive apneas accompanying bradycardia but inversely correlated with average SPO2 (%), minimum SPO2, and percentage of non-REM stage 3 sleep. There was no statistically significant difference between AOPP values before and after PAP therapy.

Conclusions

AOPP, which is an oxidative stress marker, was found to be high in OSAS patients. Especially, high levels in moderate and severe OSAS patients may be an indicator of increased morbidity. After 6 months of PAP treatment, there was no statistically significant change in these levels.

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Funding

This study funded by Ankara Numune Training and Research Hospital Scientific Research Support Fund (Grant number: 1205/2016).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Ankara City Hospital, Ankara, Turkey

    Ali Rıza Yağmur, Mehmet Ali Çetin, Süleyman Emre Karakurt & Hacı Hüseyin Dere

  2. Ankara, Turkey

    Ali Rıza Yağmur

  3. Department of Biochemistry, Ankara City Hospital, Ankara, Turkey

    Turan Turhan

Authors
  1. Ali Rıza Yağmur
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  2. Mehmet Ali Çetin
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  3. Süleyman Emre Karakurt
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  4. Turan Turhan
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  5. Hacı Hüseyin Dere
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Ethics declarations

Ethics committee approval was obtained and all subjects gave written informed consent before initiation of the study.

Conflict of interests

The authors declare that they have no conflict of interest.

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This study was presented orally at the 13th international Meeting of Otorhinolaryngology and Head & Neck Surgery, April 5–7, 2018, Ankara, Turkey.

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Yağmur, A.R., Çetin, M.A., Karakurt, S.E. et al. The levels of advanced oxidation protein products in patients with obstructive sleep apnea syndrome. Ir J Med Sci 189, 1403–1409 (2020). https://doi.org/10.1007/s11845-020-02225-3

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  • DOI: https://doi.org/10.1007/s11845-020-02225-3

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