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Dexamethasone for preventing postoperative sore throat: a meta-analysis of randomized controlled trials

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Abstract

Background

Postoperative sore throat (POST) is a common complication following tracheal intubation. The effectiveness of prophylactic dexamethasone on POST needs further elucidation.

Aims

To evaluate the effectiveness and safety of intravenous dexamethasone for the prevention of POST in patients undergoing endotracheal intubation.

Methods

Studies were identified by literature searches of PubMed, Embase, and the Cochrane database. Systematic review was performed by two independent investigators.

Results

We summarized 7 RCTs including 727 participants. Intravenous dexamethasone significantly reduced the risk of POST at 24 h [pooled risk ratio (RR) = 0.676; 95 % confidence interval (CI) 0.494–0.925; P = 0.014; heterogeneity test, I 2 = 45.8 %], as well as alleviating its severity [standardized mean difference (SMD) = −1.15; 95 % CI −1.86 to −0.45; P = 0.002; heterogeneity test, I 2 = 91.7 %]. Further sub-group analysis indicated a significant relationship between dexamethasone and reduced risk of POST when its dose was over 0.1 mg/kg. No severe adverse effects were reported.

Conclusions

Our results suggest that intravenous dexamethasone reduces the risk and severity of POST from intubation at 24 h. The effective dosage of dexamethasone for preventing the risk of POST appeared to be over 0.1 mg/kg.

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Acknowledgments

We acknowledge Guang Hao, National Center for Cardiovascular Disease Control and Research, Fuwai Hospital, National heart center, Chinese Academy of Medical Sciences and Peking Union Medical College, for assistance with the statistical analysis.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Department of Anesthesiology, Cancer Institute and Hospital, National Cancer Center, Chinese Academy of Medical Sciences, Peking Union Medical College, NO.17 Panjiayuannanli Road, Chaoyang District, Beijing, 100021, China

    L. Sun & L. Sun

  2. National Center for Cardiovascular Disease Control and Research, Fuwai Hospital, National Heart Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China

    R. Guo

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  1. L. Sun
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Correspondence to L. Sun.

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Sun, L., Guo, R. & Sun, L. Dexamethasone for preventing postoperative sore throat: a meta-analysis of randomized controlled trials. Ir J Med Sci 183, 593–600 (2014). https://doi.org/10.1007/s11845-013-1057-0

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