Skip to main content
Log in

Warfarin and topical miconazole: the potential for a clinically significant interaction

  • Letter to the Editor
  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Moran SM, Fitzgerald N, Pope M, Madden M, Vaughan CJ (2011) Warfarin anticoagulation: a survey of patient’s knowledge of their treatment. IJMS 180(4):819–822

    Article  CAS  Google Scholar 

  2. Medsafe Editorial Team (2003) Miconazole—warfarin interaction reminder. Prescr Updat 24(1):12

    Google Scholar 

  3. Pemberton MN, Oliver RJ, Theaker ED (2004) Miconazole oral gel and drug interactions. Br Dent J 196(9):529–531

    Article  PubMed  CAS  Google Scholar 

  4. O’Reilly RA, Goulart DA, Kunze KL et al (1992) Mechanisms of stereoselective interactions between miconazole and racemic warfarin in human subjects. Clin Pharmacol Ther 51:656–667

    Article  PubMed  Google Scholar 

  5. Miki A, Ohtani H, Sawada Y (2011) Warfarin and miconazole oral gel interactions: analysis and therapy recommendations based on clinical data and a pharmacokinetic model. J Clin Pharm Ther 36(6):642–650

    Article  PubMed  CAS  Google Scholar 

  6. Thirion DJG, Zanetti LA (2000) Potentiation of warfarin’s hypoprothrobinaemic effect with miconazole vaginal suppositories. Pharmacotherapy 20:98–99

    Article  PubMed  CAS  Google Scholar 

  7. Devaraj A, O’Beirne JP, Veasey R, Dunk AA (2002) Interaction between warfarin and topical miconazole cream. BMJ 325(7355):77

    Article  PubMed  CAS  Google Scholar 

  8. Kovac M, Mitic G, Kovac Z (2012) Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin. J Clin Pharm Ther 37(1):45–48

    Article  PubMed  CAS  Google Scholar 

  9. Irish Medicines Board (2012) Drug safety 47

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C. C. Ufondu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ufondu, C.C., Ferrins, P., Cushen, A. et al. Warfarin and topical miconazole: the potential for a clinically significant interaction. Ir J Med Sci 182, 153–154 (2013). https://doi.org/10.1007/s11845-012-0862-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11845-012-0862-1

Keywords

Navigation