Abstract
Objective
Whether the oncogenic human papillomavirus (HPV) infection, especially infection with the most common subtypes 16 or 18, is related to prostate carcinogenesis remains conflicting. A meta-analysis with updated data was performed to obtain a more precise estimate of the association between them.
Methods
Eligible studies were retrieved via both computer searches and review of references. The relation of HPV-16 or HPV-18 infection to prostate cancer (PC) was quantified separately. Stratified analyses based on HPV detection methods and geographic regions were also performed. Estimates of OR with 95% CI were summarized using the fixed-effect or random-effect models as appropriate.
Results
Twenty-five eligible studies were retrieved. All the 25 studies were assigned for exploring the relation of HPV-16 infection to PC, while 13 studies provided additional information on HPV-18 simultaneously. In the overall estimates, the pooled OR indicated no significant increase of PC risk related with either HPV-16 (OR 1.09; 95% CI 0.97–1.23; P heterogeneity = 0.135) or HPV-18 (OR 1.05; 95% CI 0.89–1.24; P heterogeneity = 0.314) infection. Further quantitative assay of stratified data could also not yield any significant result, except the stratified analysis on HPV-16 DNA detection, which revealed higher HPV-16 DNA prevalence in PC cases (OR 1.54; 95% CI 1.07–2.20; P heterogeneity = 0.130).
Conclusions
Even though the overall estimates did not provide a supportive evidence for the causal role of HPV in prostate carcinogenesis, higher HPV-16 DNA prevalence in PC cases from the stratified analysis still indicated a potential association between HPV infection and PC risk in our meta-analysis.
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Abbreviations
- HPV:
-
Human papillomavirus
- PC:
-
Prostate cancer
- OR:
-
Odds ratio
- CI:
-
Confidence interval
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Acknowledgments
This study was supported by National Key Technology R&D Program (No. 2008BAH27B00).
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Lin, Y., Mao, Q., Zheng, X. et al. Human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis. Ir J Med Sci 180, 497–503 (2011). https://doi.org/10.1007/s11845-011-0692-6
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DOI: https://doi.org/10.1007/s11845-011-0692-6