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Profiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care

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Abstract

Aim

To examine the prognostic importance of absolute values and change in values of BNP in patients with stable heart failure (HF).

Methods

Five-hundred and fifty-nine patients attending a disease management programme were categorized into tertiles of BNP (group 1; ≤95 pg/ml, group 2; 96–249 pg/ml and group 3; ≥250 pg/ml). A change in BNP between two stable visits was recorded. Patients were followed up for 1 year for death and a composite morbidity measure of HF hospitalization, all-cause hospitalization, unscheduled visits for clinical deterioration(UC) of HF using survival analysis.

Results

The risk of the combined morbidity outcome increased with increasing tertiles of BNP (Log rank = 17.8 (2), p < 0.001). Furthermore, a 50 and 25% increase in BNP predicted morbidity in stable HF patients with an initial BNP > 200 pg/ml (p = 0.02) and >450 pg/ml (p = 0.03), respectively.

Conclusion

In a stable community HF population, an elevated BNP or an increase in BNP predicts an adverse prognosis thereby potentially identifying a population in need of closer clinical follow-up.

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Conflicts of interest

KMCD and ML have received honoraria from Biosyn. There are no other conflicts of interest.

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Authors and Affiliations

  1. Department of Cardiology, Heart Failure Unit, St. Vincent’s University Hospital and University College Dublin, Elm Park, Dublin 4, Ireland

    A. Jan, N. F. Murphy, C. O’Loughlin, M. Ledwidge & K. McDonald

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  1. A. Jan
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  2. N. F. Murphy
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  3. C. O’Loughlin
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  4. M. Ledwidge
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  5. K. McDonald
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Correspondence to K. McDonald.

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Jan, A., Murphy, N.F., O’Loughlin, C. et al. Profiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care. Ir J Med Sci 180, 355–362 (2011). https://doi.org/10.1007/s11845-011-0689-1

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  • DOI: https://doi.org/10.1007/s11845-011-0689-1

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