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Effect of natural cross-linker on swelling and structural stability of kappa-carrageenan/hydroxyethyl cellulose pH-sensitive hydrogels

  • Polymer, Industrial Chemistry, Fluidization, Particle Technology
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Abstract

Genipin cross-linked kappa-carrageenan/hydroxyethyl cellulose hydrogels were prepared and the effect of cross-linking on hydrogels characteristics was investigated. Swelling and transform mechanisms of both native and cross-linked gels in different pH were also studied. We found that the concentration of genipin affects the physical stability of gels. The optimum concentration that a cross-linked hydrogel molecular structure can be in its most stable form is also discussed. Native hydrogels exhibited more swelling in alkaline medium than acidic and neutral; however, by increasing the cross-linker concentration, the swelling ability in neutral medium increased so that genipin cross-linked hydrogels could swell in pH 7 more than in pH 1.2 and 12. Fourier transform infrared spectroscopy (FTIR) was applied to study the formation of new bonding due to genipin reactions and explain hydrogels’ stability in various concentrations. Differential scanning calorimetry (DSC) measurements reveal that by increasing genipin, the gel ability to hold water increases to some point and then decreases due to less structural stability. X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM) tests were performed to study the crystallinity changes and microstructure of hydrogels. Finally, the power law model was applied to study the transform mechanism of hydrogels.

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References

  1. Ch. Ch. Lin and A. T. Metters, Adv. Drug. Deliv. Rev., 58, 1379 (2006).

    Article  CAS  Google Scholar 

  2. S. Ch. Chen, Y.Ch. Wu, F. L. Mi, Y.H. Lin, L. Ch. Yu and H.W. Sung, J. Control. Release, 96, 285 (2004).

    Article  CAS  Google Scholar 

  3. M.V. Risbud, A.A. Hardikar, S.V. Bhat and R. R. Bhonde, J. Control. Release, 68, 23 (2000).

    Article  CAS  Google Scholar 

  4. C.T. Aranilla, F. Yoshii, A. M. Rosa and K. Makuuchi, Radiat. Phys. Chem., 55(12), 127 (1999).

    Article  Google Scholar 

  5. M. Zhai, Y. Zhang, J. Ren, M. Yi, H. Ha and J. F. Kennedy, Carbohyd Polym., 58, 35 (2004).

    Article  CAS  Google Scholar 

  6. O. Sipahigil and B. Dortunc, Int. J. Pharm., 228, 119 (2001).

    Article  CAS  Google Scholar 

  7. H. Sjoberg, S. Persson and N. C. Lelham, J. Control. Release, 59, 391 (1999).

    Article  CAS  Google Scholar 

  8. M. J. Carlucci, C. A. Pujol, A. M. Cianci, M. D. Noseda, M. C. Matulewicz, E. B. Damonte and A. S. Cerezo, Int. J. Biol. Macromol., 20 (1997).

  9. K. B. Guiseley, US Patent, 4,096,327 (1978).

  10. A. L. Daniel-da-Silva, A.B. Lopes, A. M. Gil and R. N. Correia, J. Mater. Sci., 42, 8581 (2007).

    Article  CAS  Google Scholar 

  11. W. Wang, J. Wang, Y. Kang and A. Wang, Composites: Part B., 42, 809 (2011).

    Article  Google Scholar 

  12. S.B. Lin, J. H. Wu, K. D. Yao, K.Y. Cai, C. M. Xiao and C. J. Jiang, Compos Interface., 11, 271 (2004).

    Article  CAS  Google Scholar 

  13. I. I. Muhamad, L. S. Fen, H. Ng. Hui and N. A. Mustapha, Carbohyd Polym., 83, 1207 (2011).

    Article  CAS  Google Scholar 

  14. R. Meena, K. Prasad and A. K. Siddhanta, Food Hydrocolloid., 23, 497 (2009).

    Article  CAS  Google Scholar 

  15. R. Touyama, Y. Takeda, K. Inoue, I. Kawamura, M. Yatsuzuka, T. Ikumoto, T. Shingu, T. Yokoi and H. Inouye, Chem. Pharm. Bull., 42, 668 (1994).

    Article  CAS  Google Scholar 

  16. A. Katchalsky and I. Michaeli, J. Polym. Sci., 15, 69 (1955).

    Article  CAS  Google Scholar 

  17. L. Brannon-Peppas and N. A. Peppas, Chem. Eng. Sci., 46, 715 (1991).

    Article  CAS  Google Scholar 

  18. J. Ricka and T. Tanaka, Macromolecules., 17, 2916 (1984).

    Article  CAS  Google Scholar 

  19. S. Francis, M. Kumar and L. Varshney, Radiat. Phys. and Chem., 69, 481 (2004).

    Article  CAS  Google Scholar 

  20. S.W. Lee, J.M. Lim, S. H. Bhoo, Y. S. Paik and T. R. Hahn, Analytica Chemica Acta, 480, 267 (2003).

    Article  CAS  Google Scholar 

  21. R. Jing and H. Hongfei, Eur. Polym. J., 37, 3413 (2001).

    Article  Google Scholar 

  22. S. Gorgieva and V. Kokol, Carbohyd Polym., 85, 664 (2011).

    Article  CAS  Google Scholar 

  23. G. P. Palace, R. Fitzpatrick, K. V. Tran, H. C. Phoebe Jr. and K. Norton, Biochim. Biophys. Acta, 1472, 509 (1999).

    Article  CAS  Google Scholar 

  24. F. Q. Han, B. Shao, Q.W. Wang, C.G. Guo and Y. X. Liu, Pigm. Resin. Technol., 39, 156 (2010).

    CAS  Google Scholar 

  25. T. T. Lau, C. Wang and D. Wang, Compos. Sci. Technol., 70, 1909 (2010).

    Article  CAS  Google Scholar 

  26. E. Daniela and E. O. Camelia, Chem. Eng. Comm., 10, 1269 (2008).

    Google Scholar 

  27. C. S. Brazel and N. A. Peppas, Polymer, 40, 3383 (1999).

    Article  CAS  Google Scholar 

  28. N. A. Peppas, Pharm. Acta Helv., 60, 110 (1985).

    CAS  Google Scholar 

  29. P. L. Ritger and N. A. Peppas, J. Control. Release, 5, 37 (1987).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Faculty of Chemical Engineering, Universiti Teknologi Malaysia Johor Bahru, Johor, 81310, Malaysia

    Hadi Hezaveh & Ida Idayu Muhamad

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  1. Hadi Hezaveh
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  2. Ida Idayu Muhamad
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Correspondence to Ida Idayu Muhamad.

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Hezaveh, H., Muhamad, I.I. Effect of natural cross-linker on swelling and structural stability of kappa-carrageenan/hydroxyethyl cellulose pH-sensitive hydrogels. Korean J. Chem. Eng. 29, 1647–1655 (2012). https://doi.org/10.1007/s11814-012-0056-6

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  • DOI: https://doi.org/10.1007/s11814-012-0056-6

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