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Recrystallization of tetracycline hydrochloride using supercritical anti-solvent process

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Abstract

Tetracycline hydrochloride (TTC) was micronized by an Aerosol Solvent Extraction System (ASES) using supercritical CO2. The effects of solvent, pressure and temperature of CO2, solution concentration, and solution feed rate on particle size were investigated. Mean particle sizes of processed TTC were 0.16–0.31 μm, but the morphologies of processed particles were affected by agglomeration between the primary particles. Mean particle sizes of unprocessed TTC were ca. 200 μm and the shapes were irregular with rough surfaces. Especially, particle sizes increased from 0.18 to 0.31 μm as CO2 temperature increased. In addition, particle sizes increased from 0.18 to 0.23 μm as TTC concentration increased. Powder X-Ray diffractometry revealed that processed particles were amorphous whereas unprocessed particles showed strong crystallinity.

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Authors and Affiliations

  1. School of Chemical & Biological Engineering and Institute of Chemical Process, Seoul National University, San 56-1, Sillim-Dong, Gwanak-gu, Seoul, 151-744, Korea

    Junho Chu, Hanho Lee, Hwayong Kim & Youn-Woo Lee

Authors
  1. Junho Chu
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  2. Hanho Lee
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  3. Hwayong Kim
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  4. Youn-Woo Lee
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Correspondence to Youn-Woo Lee.

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Chu, J., Lee, H., Kim, H. et al. Recrystallization of tetracycline hydrochloride using supercritical anti-solvent process. Korean J. Chem. Eng. 26, 1119–1124 (2009). https://doi.org/10.1007/s11814-009-0186-7

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  • DOI: https://doi.org/10.1007/s11814-009-0186-7

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