Abstract
A series of attempts to enhance the bioavailability of water insoluble drugs have been made by the fine grinding technique using a planetary ball mill in wet milling process. Here, the possibility of improving the dissolution properties of water insoluble drugs such as ursodeoxycholic acid (UDCA), diphenyl hydrantoin (phenytoin) and biphenyl dimethyl dicarboxylate (DDB) based on ultra-fine grinding process has been discussed with comparison to experimental data. Also examined was the intrinsic bioavailability estimated based on a molecular modeling approach and thermophysical data.
This is a preview of subscription content, log in via an institution to check access.
References
W. L. Chow and S. Riegelman, J. Pharm. Sci., 60, 1281 (1971).
J. C. Chaumeil, Meth. Find. Clin. Pharmacol., 20, 211 (1998).
K. Yamamoto, M. Nakano, T. Arita and Y. Nakai, J. Pharmacokinet. Biopharm., 2, 487 (1974).
M. Morita, Y. Nakai, E. Fukuoka and S. Nakajima, Chem. Pharm. Bull., 32, 4076 (1984).
J. Pirttimaki, E. Laine, J. Ketolainen and P. Paranen, Int. J. Pharm., 95, 93 (1993).
S. Piyarom, E. Yonemochi, T. Oguchi and K. Yamamoto, J. Pharm. Pharmacol., 49, 384 (1997).
S. H. Yalkowsky and S. Banerjee, in Aqueous Solubility, Methods’ of Estimation for Organic Compounds, Marcel Dekker, New York, NY (1992).
A. S. B. Christel, N. Ulf, L. Kristina and Per Artursson, Pharmaceutical Research, 19, 182 (2002).
H.Y. Chung, E. Yonemochi, T. Saito, K. Terada, Y. Tozuka, T. Oguchi, K. Yamamoto, H. Y. Chung and W. S. Choi, Int. J. Pharm., 255, 49 (2003).
H. I. Kim, S. S. Kwak, H. Y. Chung, H. Y. Chung, K. Yamamoto, T. Oguchi, Y. Tozuka, E. Yonemochi and K. Terada, Int. J. of Mineral Processing, 74, S165 (2004).
W. S. Choi, S. S. Kwak and H. I. Kim, Asian Journal of Pharmaceutical Sciences, 1, 27 (2006).
W. S. Choi, H. Y. Chung, B. Y. Yoon and S. S. Kim, Powder Technology, 115, 209 (2001).
C. Nystrom, J. Mazur, M. I. Darneff and M. Glazer, J. Pharm. Pharmacol., 37, 217 (1985).
W. J. Egan, K. M. Jr. Merz and J. J. Baldwin, J. Med. Chem., 43, 3867 (2000).
D. Rogers and A. J. Hopfinger, J. Chem. Inf. Comput. Sci., 34, 854 (1994).
P. D. Mosier and P. C. Jurs, J. Chem. Inf. Comput. Sci., 42, 1460 (2002).
ADME modules of Cerius 2, Version 4.10, Accelrys Inc., San Diego CA.
ChemIDplus Advanced, http://chem.sis.nlm.nih.gov/chemidplus.
W. M. Meylan and P. H. Howard, in PCGEMS & EPI (Sept 1994, Final Report), S.B. Robert, U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, DC; prepared by Syracuse Research Corporation, Environmental Science Center, Syracuse, NY 13210 (1994).
A. Cheng and K. M. Merz, J. Med. Chem., 46, 3572 (2003).
W. Arlt, in Private communication on the prediction of thermophysical data, University of Erlangen, Germany (2005).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kim, J., Jung, D.H., Rhee, H. et al. Improvement of bioavailability of water insoluble drugs: Estimation of intrinsic bioavailability (Short Communication). Korean J. Chem. Eng. 25, 171–175 (2008). https://doi.org/10.1007/s11814-008-0031-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11814-008-0031-4