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Long-term survival of airway silicone stents in patients with central airway stenosis or obstruction due to thoracic malignancy

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Abstract

Objectives

Silicone airway stents are used to manage central airway stenosis or obstruction, although their impact on long-term survival remains unknown in patients with central airway stenosis or obstruction due to thoracic malignancy. In this study, we retrospectively analyzed the impact of silicone stents on survival.

Methods

We retrospectively analyzed clinical data of 106 patients with central airway stenosis or obstruction due to thoracic malignancy treated by stenting at Toho University Omori Medical Center between 1998 and 2018.

Results

Patients treated with silicone stents had significantly higher survival rates than patients treated with metallic stents (p = 0.0173). Silicone stents patients also had significantly more additional treatments for thoracic malignancy after stenting than metallic stents patients (p = 0.0007). Notably, significantly more silicone stents patients underwent chemoradiotherapy or radiotherapy (p = 0.0268, p = 0.0300). During multivariate analyses, the additional treatment, including chemoradiotherapy or radiotherapy, was an independent optimal prognostic factor.

Conclusions

Silicone stents patients had significantly higher survival rates than metallic stents patients. Although stenting for airway stenosis or obstruction due to thoracic malignancy may be mainly palliative, additional treatments after stenting should be considered to improve the prognoses of patients with airway stenosis or obstruction due to thoracic malignancy.

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Acknowledgments

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Funding

This research did not receive any grants from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Division of Chest Surgery, Department of Surgery, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan

    Akira Iyoda, Yoko Azuma, Atsushi Sano, Takashi Sakai, Satoshi Koezuka & Hajime Otsuka

  2. Division of Respiratory Medicine, Toho University School of Medicine, Tokyo, Japan

    Kazutoshi Isobe, Susumu Sakamoto & Yujiro Takai

  3. Nishiyokohama International Hospital, Kanagawa, Japan

    Keigo Takagi

Authors
  1. Akira Iyoda
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  2. Yoko Azuma
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  3. Atsushi Sano
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  4. Takashi Sakai
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  5. Satoshi Koezuka
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  6. Hajime Otsuka
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  7. Kazutoshi Isobe
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  8. Susumu Sakamoto
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  9. Yujiro Takai
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  10. Keigo Takagi
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Contributions

YA, AS, TS, SK, HO, KI, SS, KT, and AI have been involved in the conception and design of the study. AI wrote the manuscript. YA, AS, TS, SK, and HO collected data. KI, SS, and KT supervised this study. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Akira Iyoda.

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We have no conflicts of interest in this study.

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Iyoda, A., Azuma, Y., Sano, A. et al. Long-term survival of airway silicone stents in patients with central airway stenosis or obstruction due to thoracic malignancy. Gen Thorac Cardiovasc Surg 69, 1303–1307 (2021). https://doi.org/10.1007/s11748-021-01634-0

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  • DOI: https://doi.org/10.1007/s11748-021-01634-0

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