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Risk factor of bronchopleural fistula after general thoracic surgery: review article

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Abstract

Objective

The aim of this article was to clarify recent risk factors for the early bronchopleural fistula after anatomical lung resection.

Methods

Reports on early bronchopleural fistula after anatomical lung resection in adults, including information on risk factors, published between 2006 and 2016 were reviewed and our institutional data were evaluated. The early period was defined as within 30 days from surgery or as described early in the manuscript.

Results

A total of seven retrospective observational articles were selected. Four articles investigated lobectomy and pneumonectomy, while the other three articles investigated only pneumonectomy. The surgical procedure, preoperative therapy, complications after surgery, right side, patient age, past history, and tumor residuals were mentioned as risk factors of bronchopleural fistula. Our data concluded that neoadjuvant therapy and a right lower lobe location were risk factors after a lobectomy, while a right side and complete pneumonectomy were risk factors after a pneumonectomy.

Conclusions

Although recent studies have reached nearly the same conclusions as older reports, continuous research of potential risk factor is needed as therapeutic procedures continue to evolve.

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Abbreviations

BPF:

Bronchopleural fistula

NSCLC:

Non-small cell lung cancer

EGFR:

Epithelial growth factor receptor

TKI:

Tyrosine kinase inhibitor

ALK:

Anaplastic lymphoma kinase

PD-L1:

Programmed cell death ligand 1

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Authors and Affiliations

  1. Department of General Thoracic Surgery, Meiwa Hospital, 4-31, Agenaruo-chou, Nishinomiya city, Hyogo, Japan

    Masaya Okuda

  2. Department of General Thoracic, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa, Japan

    Tetsuhiko Go & Hiroyasu Yokomise

Authors
  1. Masaya Okuda
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  2. Tetsuhiko Go
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  3. Hiroyasu Yokomise
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Correspondence to Masaya Okuda.

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Okuda, M., Go, T. & Yokomise, H. Risk factor of bronchopleural fistula after general thoracic surgery: review article. Gen Thorac Cardiovasc Surg 65, 679–685 (2017). https://doi.org/10.1007/s11748-017-0846-1

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  • DOI: https://doi.org/10.1007/s11748-017-0846-1

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