Abstract
A 59-year-old male, whose chest X-ray showed an abnormal shadow, visited us for further study. Laboratory examination showed the elevated level for both carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) in serum, and the chest X-ray and computed tomography showed an anterior mediastinal mass. Under a diagnosis of thymic malignancy, extended thymectomy with combined resection of the pleura and pericardium was performed. Histopathological findings showed a well-differentiated adenocarcinoma of the thymus, in which CA19-9 and CEA were positive immuno-histochemically. The level of serum CA19-9 and CEA returned to normal ranges postoperatively, however, the tumor recurred in local site with re-elevation of these tumor markers at the 20th month after surgery. He died at 4th month after the first recurrence despite the intensive chemotherapy. We report an extremely rare case of primary thymic adenocarcinoma with the production of CA19-9 and CEA.
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References
Wick MR, Weiland LH, Scheithauer BW, Bernatz PE. Primary thymic carcinomas. Am J Surg Pathol 1982; 6: 612–30.
Truong LD, Mody DR, Cagle PT, Jackson-York GL, Schwartz MR, Wheeler TM. Thymic carcinoma: A clinicopathologic study of 13 cases. Am J Surg Pathol 1990; 14: 151–66.
Suster S, Rosai J. Thymic carcinoma. A clinicopathologic study of 60 cases. Cancer 1991; 67: 1025–32.
Makino Y, Asada S, Suzuki T, Hashimoto M. A case of adenocarcinoma of the thymus (Eng abstr). Jpn J Thorac Cardiovasc Surg 1988; 46: 1168–71.
Shimosato Y, Mukai K. Tumors of the mediastinum. In Rosai J, ed. Atlas of Tumor Pathology, Series 3, Fascicle 21, Washington DC, Armed Forces Institute of Pathology, 1997; 120–57.
Suster S, Moran CA. Thymic carcinoma: Spectrum of differentiation and histologic types. Pathology 1998; 30: 111–22.
Ritter JH, Wick MR. Primary carcinomas of the thymus gland. Semin in Diagn Pathol 1999; 16: 18–31.
Shimono M, Hiraki A, Ueoka H, Tanimoto Y, Aoe M, Sakae K, et al. Successful treatment with concurrent chemoradiotherapy followed by surgery for a patient with thymic adenocarcinoma. Anticancer Res 2001; 21: 2519–22.
Rosai J, Levine GD. Tumors of the thymus. Atlas of Tumor Pathology, 2nd Series, Fascicle 13, Washington, D.C.: Armed Forces Institute of Pathology, 1976: 34–153.
Levine GD, Rosai J. Thymic hyperplasia and neoplasia: A review of current concepts. Hum Pathol 1978; 9:495–515.
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Misao, T., Yamamoto, Y., Nakano, H. et al. Primary thymic adenocarcinoma with production of carbohydrate antigen 19-9 and carcinoembryonic antigen. Jpn J Thorac Caridovasc Surg 52, 30–32 (2004). https://doi.org/10.1007/s11748-004-0058-3
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DOI: https://doi.org/10.1007/s11748-004-0058-3