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Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice

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Lipids

Abstract

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.

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Abbreviations

CLA:

conjugated linoleic acid

DMEM:

Dulbecco's modified Eagle's medium

FBS:

fetal bovine serum

LPL:

lipoprotein lipase

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Authors and Affiliations

  1. Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin-Madison, 1925 Willow Dr., 53706, Madison, Wisconsin

    Yeonhwa Park, Jayne M. Storkson, Karen J. Albright, Wei Liu & Michael W. Pariza

Authors
  1. Yeonhwa Park
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  2. Jayne M. Storkson
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  3. Karen J. Albright
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  4. Wei Liu
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  5. Michael W. Pariza
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Correspondence to Michael W. Pariza.

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Park, Y., Storkson, J.M., Albright, K.J. et al. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34, 235–241 (1999). https://doi.org/10.1007/s11745-999-0358-8

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