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Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme

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Lipids

Abstract

Sesamol, a nonoil component of sesame seed oil, inhibited growth, fatty acid synthesis, and desaturation by Mucor circinelloides in vivo. Although sesamol also inhibited the growth of other fungi and yeasts, its effect on the lipid metabolism of M. circinelloides was exceptional. An enzymological study demonstrated that sesamol affected lipid synthesis primarily by the inhibition of malic enzyme activity, thereby limiting the NADPH supply for fatty acid synthesis and desaturation. Sesamol itself had no inhibitory effect on malic enzyme activity in vitro. A metabolite of sesamol is therefore probably responsible for the in vivo effects of sesamol on lipid metabolism.

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Author notes

  1. Andrew Kendrick

    Present address: Roche Lipids Ltd., Hennor, Derbyshire, UK

Authors and Affiliations

  1. Department of Biological Sciences, University of Hull, HU6 7RX, Hull, UK

    James P. Wynn, Andrew Kendrick & Colin Ratledge

Authors
  1. James P. Wynn
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  2. Andrew Kendrick
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  3. Colin Ratledge
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Correspondence to James P. Wynn.

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Wynn, J.P., Kendrick, A. & Ratledge, C. Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme. Lipids 32, 605–610 (1997). https://doi.org/10.1007/s11745-997-0077-1

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  • DOI: https://doi.org/10.1007/s11745-997-0077-1

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