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Vitamin D and Evening Primrose Oil Administration Improve Glycemia and Lipid Profiles in Women with Gestational Diabetes

  • Original Article
  • Published:
Lipids

An Erratum to this article was published on 03 March 2016

Abstract

Limited data are available assessing the effects of vitamin D and evening primrose oil (EPO) administration on markers of insulin resistance and lipid concentrations in gestational diabetes mellitus (GDM). This study was designed to evaluate the effects of vitamin D and EPO administration on insulin resistance and lipid concentrations among women with GDM. In this prospective randomized, double-blind, placebo-controlled clinical trial, 60 participants with GDM were divided into 2 groups of either 1000 IU vitamin D3 and 1000 mg EPO or placebo for 6 weeks. At the beginning and end of the study, fasting blood samples were obtained from the participants to measure related variables. After 6 weeks of intervention, changes in fasting plasma glucose (−3.6 ± 7.5 vs. +1.5 ± 11.4 mg/dL, P = 0.04), serum insulin concentrations (−2.0 ± 5.3 vs. +4.6 ± 10.7 µIU/mL, P = 0.004), homeostasis model of assessment (HOMA) insulin resistance (−0.5 ± 1.1 vs. +1.1 ± 2.5, P = 0.003), HOMA-B cell function (−7.7 ± 23.3 vs. +17.4 ± 42.9, P = 0.007) and the quantitative insulin sensitivity check index (+0.01 ± 0.02 vs. −0.01 ± 0.02, P = 0.007) in the vitamin D plus EPO group were significantly different from the placebo group. In addition, compared with the placebo, vitamin D and EPO supplementation resulted in significant reductions in serum TAG (−20.0 ± 54.3 vs. +34.3 ± 38.2 mg/dL, P < 0.001), VLDL (−4.0 ± 10.9 vs. +6.9 ± 7.6 mg/dL, P < 0.001), TC (−22.1 ± 32.6 vs. +5.3 ± 20.1 mg/dL, P < 0.001), LDL concentrations (−18.0 ± 25.5 vs. +1.8 ± 15.7 mg/dL, P = 0.001) and TC/HDL (−0.3 ± 0.4 vs. +0.3 ± 0.5 mg/dL, P < 0.001). We did not observe any significant effect of vitamin D and EPO supplementation on serum HDL concentrations.

Clinical trial registration number: http://www.irct.ir: IRCT201509115623N52.

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Abbreviations

CVD:

Cardiovascular disease

EPO:

Evening primrose oil

EFAs:

Essential fatty acids

FPG:

Fasting plasma glucose

GDM:

Gestational diabetes mellitus

GLA:

Gamma-linolenic acid

HOMA-IR:

Homeostasis model of assessment-estimated insulin resistance

HOMA-B:

Homeostasis model of assessment-estimated B cell function

HDL:

High-density lipoprotein

LDL:

Low-density lipoprotein

MUFA:

Monounsaturated fatty acid

PUFA:

Polyunsaturated fatty acid

QUICKI:

Quantitative insulin sensitivity check index

SFA:

Saturated fatty acid

TAG:

Triacylglycerol

TC:

Total cholesterol

VLDL:

Very low-density lipoprotein

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Acknowledgments

The present study was founded by a grant from the Vice Chancellor for Research, AUMS, Kashan, Iran.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran

    Mehri Jamilian

  2. Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Maryam Karamali

  3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, PO Box 8715988141, Kashan, Islamic Republic of Iran

    Mohsen Taghizadeh, Nasrin Sharifi, Zahra Jafari & Zatolla Asemi

  4. Barij Medicinal Plants Research Center, Kashan, Islamic Republic of Iran

    Mohammad Reza Memarzadeh & Mahnaz Mahlouji

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  1. Mehri Jamilian
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  2. Maryam Karamali
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Correspondence to Zatolla Asemi.

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Jamilian, M., Karamali, M., Taghizadeh, M. et al. Vitamin D and Evening Primrose Oil Administration Improve Glycemia and Lipid Profiles in Women with Gestational Diabetes. Lipids 51, 349–356 (2016). https://doi.org/10.1007/s11745-016-4123-3

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  • DOI: https://doi.org/10.1007/s11745-016-4123-3

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