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Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids

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Lipids

Abstract

Long-chain PUFA play an important role in early human neurodevelopment. Significant inverse correlations were reported between values of trans isomeric and long-chain PUFA in plasma lipids of preterm infants and children aged 1–15 yr as well as in venous cord blood lipids of full-term infants. Here we report FA compositional data of cord blood vessel wall lipids in 308 healthy, full-term infants (gestational age: 39.7±1.2 wk, birth weight: 3528±429 g, mean±SD). The median (interquartile range) of the sum of 18-carbon trans FA was 0.22 (0.13)% w/w in umbilical artery and 0.16 (0.10)% w/w in umbilical vein lipids. Nonparametric correlation analysis showed significant inverse correlations between the sum of 18-carbon trans FA and both arachidonic acid and DHA in artery (r=−0.38, P<0.01, and r=−0.20, P<0.01) and vein (r=−0.36, P<0.01, and −0.17, P<0.01) wall lipids. In addition, the sum of 18-carbon trans FA was significantly positively correlated to Mead acid, a general indicator of EFA deficiency, in both artery (r=+0.35, P<0.01) and vein (r=+0.31, P<0.01) wall lipids. The present results obtained in a large group of full-term infants suggest that maternal trans FA intake is inversely associated with long-chain PUFA status of the infant at birth.

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Abbreviations

Cis unsaturated FA: 18∶1n−9:

cis-9-oleic acid

18∶2n−6:

all-cis-9,12-linoleic acid

18∶3n−3:

all-cis-9, 12,15α-linolenic acid

20∶3n−9:

all-cis-5,8,11-eicosatrienoic acid

20∶4n−6:

all-cis-5,8,11,14-arachidonic acid

22∶6n−3:

all-cis-4,7,10,13,16,19-docosahexaenoic acid

Trans isomeric FA: t-16:

trans-7-hexadecenoic acid

t-18∶1:

trans-9/11-octadecenoic acid

tt-18∶2:

all-trans-9, 12-octadecadienoic acid

tc-18∶2:

trans-9, cis-12-octadecadienoic acid

ct-18∶2:

cis-9, trans-12-octadecadienoic acid

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Author information

Authors and Affiliations

  1. Department of Paediatrics, University of Pécs, József A. u. 7., H-7623, Pécs, Hungary

    Tamás Decsi & Szilárd Molnár

  2. NUMICO Research Group, D-61381, Friedrichsdorf, Germany

    Günther Boehm

  3. Perinatal Nutrition & Development Unit, Department of Pediatrics/Obstetrics and Gynaecology, University of Groningen, 9700 RB, Groningen, The Netherlands

    H. M. Ria Tjoonk & E. Rudy Boersma

  4. Pathology and Laboratory Medicine, University Hospital Groningen, 9700 RB, Groningen, The Netherlands

    D. A. Janneke Dijck-Brouwer & Frits A. J. Muskiet

  5. Department of Neurology, University of Groningen, 9700 RB, Groningen, The Netherlands

    Mijna Hadders-Algra

  6. Laboratory Center, University Hospital Groningen, 9700 RB, Groningen, The Netherlands

    Ingrid A. Martini

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  1. Tamás Decsi
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  2. Günther Boehm
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  3. H. M. Ria Tjoonk
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  4. Szilárd Molnár
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  8. Frits A. J. Muskiet
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  9. E. Rudy Boersma
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Correspondence to Tamás Decsi.

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Decsi, T., Boehm, G., Tjoonk, H.M.R. et al. Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids. Lipids 37, 959–965 (2002). https://doi.org/10.1007/s11745-006-0987-y

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  • DOI: https://doi.org/10.1007/s11745-006-0987-y

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