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Supplementation with CLA: Isomer incorporation into serum lipids and effect on body fat of women

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Lipids

Abstract

Animal studies have suggested that CLA, a natural component of meat and dairy products, may confer beneficial effects on health. However, human studies using supplementation with CLA have produced contradictory results. The aim of the present study was to further investigate the effect of CLA supplementation on human body fat, serum leptin, and serum lipids, as well as the incorporation of CLA isomers into serum lipids classes. Sixteen young healthy nonobese sedentary women received 2.1 g of CLA (divided equally between the cis,trans-9,11 and trans,cis-10,12 isomers) daily for 45 d and placebo for 45 d in a randomized double-blind crossover design. Body fat was estimated (by measurement of skinfold thickness at 10 sites), and blood was sampled at the beginning, middle, and end of the entire intervention period; an additional blood sample was obtained 2 wk thereafer. No significant differences in energy, carbohydrate, lipid, or protein intake existed between the CLA and placebo intake periods. No significant differences were found in body fat or serum leptin, TAG, total cholesterol, HDL-cholesterol, and alanine aminotransferase between CLA and placebo. The CLA isomer content of serum TAG, phospholipids, and total lipids increased 2–5 times with CLA supplementation (P<0.05). In contrast, the CLA content of cholesteryl esters did not change significantly. The period of 2 wk after the end of CLA supplementation was sufficient for its washout from serum lipids. These data indicate that supplementation with 2.1 g of CLA daily for 45 d increased its levels in blood but had no effect on body composition or the lipidemic profile of nonobese women.

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Abbreviations

ALT:

alanine aminotransferase

CE:

cholesteryl esters

PL:

phospholipids

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Authors and Affiliations

  1. Department of Physical Education and Sport Science, TEFAA, University of Thessaloniki, 541 24, Thessaloniki, Greece

    Anatoli Petridou & Vassilis Mougios

  2. Department of Physical Education and Sport Science, Consulting, 20249, Hamburg, Germany

    Angelos Sagredos

Authors
  1. Anatoli Petridou
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  2. Vassilis Mougios
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  3. Angelos Sagredos
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Correspondence to Vassilis Mougios.

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Petridou, A., Mougios, V. & Sagredos, A. Supplementation with CLA: Isomer incorporation into serum lipids and effect on body fat of women. Lipids 38, 805–811 (2003). https://doi.org/10.1007/s11745-003-1129-2

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  • DOI: https://doi.org/10.1007/s11745-003-1129-2

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