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Cardiac and vascular structure and function are related to lipid peroxidation and metabolism

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Lipids

Abstract

The present study investigated possible relationships between left ventricular mass, intima-media thickness of the carotid artery (IMT), total arterial compliance, and lipid status in a population sample of 58 apparently healthy subjects aged 20 to 69. By stepwise multiple regression analysis, including age, blood pressure, and smoking, left ventricular mass index, measured by M-mode echocardiography, increased by 13.0 g/m2 for each 1 standard deviation (SD=0.11 μM, r=0.60, P<0.01) increase in plasma malondialdehyde and 9.50 g/m2 per SD increase in plasma 8-iso-prostaglandin F2α in women only (SD=8.88 ng/L, r=0.44, P=0.01). Each 1-SD (SD=0.27 g/L) increase in apolipoprotein B was associated with a 63 μm increase in IMT (r=0.47, P=0.01) and a 0.27 mL/min/m2/mm Hg (r=−0.60, P<0.01) decrease in stroke index/pulse pressure ratio, reflecting total arterial compliance in women. In men, each 1-SD increase in the proportion of stearic acid (18∶0) in serum cholesterol esters (SD=0.12 percent units) reduced the transmitral E/A ratio, measured by Doppler echocardiography, reflecting left ventricular diastolic function, by 0.10 units (r=−0.29, P<0.05). Thus, important cardiovascular characteristics, such as left ventricular mass, left ventricular diastolic function, carotid IMT, and total arterial compliance, were independently predicted by indices of lipid metabolism and peroxidation in apparently healthy subjects.

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Abbreviations

AVPD:

atrio-ventricular valve plane displacement

CHD:

coronary heart disease

EF:

ejection fraction

IMT:

intima-media thickness

8-iso-PGF2α :

8-iso-prostaglandin F2α

LVEDD:

left ventricular diameter in end-diastole

LVESD:

left ventricular diameter in end-systole

LVMI:

left ventricular mass index

MDA:

malondialdehyde

PL:

phospholipid

PP:

pulse pressure=systolic blood pressure—diastolic blood pressure

SI:

stroke index

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Authors and Affiliations

  1. Department of Medical Sciences/Internal Medicine, University Hospital, SE-751 85, Uppsala, Sweden

    Peter Steer, Jonas Millgård, Dennis M. Sarabi & Lars Lind

  2. Department of Public Health and Caring Sciences/Geriatrics, University Hospital, SE-751 85, Uppsala, Sweden

    Samar Basu & Bengt Vessby

  3. Division of Internal Medicine, Karolinska Institutet Danderyd Hospital, SE-182 88, Danderyd, Sweden

    Thomas Kahan & Magnus Edner

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  1. Peter Steer
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  2. Jonas Millgård
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Correspondence to Lars Lind.

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Steer, P., Millgård, J., Sarabi, D.M. et al. Cardiac and vascular structure and function are related to lipid peroxidation and metabolism. Lipids 37, 231–236 (2002). https://doi.org/10.1007/s11745-002-0885-3

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  • DOI: https://doi.org/10.1007/s11745-002-0885-3

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