Abstract
15R-Prostaglandin E2 (PGE2) methyl ester 15-acetate (1) was isolated from the R-variety of the Caribbean sea whip coral, Plexaura homomalla collected in the Florida Keys. It was present in coral samples from separate collections in 2–10% of the abundance of the major prostaglandin component, PGA2 methyl ester 15-acetate. The structure of 1 was assigned based on one- and two-dimensional 1H NMR, HPLC, and LC-MS analyses. A sample of the S-variety of P. homomalla was found to contain a similar abundance of the corresponding 15S product, prostaglandin E2 methyl ester 15-acetate. The significance of PGE acetylation is discussed in relation to the proposed mechanism of PGA synthesis in the coral.
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Abbreviations
- CID:
-
collision-induced dissociation
- CIS:
-
coordination ion spray
- ESI:
-
electrospray ionization
- Me:
-
methyl ester
- PGA2 :
-
prostaglandin A2
- PGE2 :
-
prostaglandin E2
- SP:
-
straight-phase
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Schneider, C., Manier, M.L., Hachey, D.L. et al. Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla . Lipids 37, 217–221 (2002). https://doi.org/10.1007/s11745-002-0883-5
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DOI: https://doi.org/10.1007/s11745-002-0883-5