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Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men

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Lipids

Abstract

Trans monounsaturated fatty acids (TFA) are hypercholesterolemic compared to oleic acid to a degree approaching or equivalent to saturated FA. However, it is unknown to what extent these effects may be due to cholesterol lowering by oleic acid rather than elevation by saturated FA and TFA. In order to better understand the impact of replacing TFA in foods, it is first necessary to know the relative lipid-modifying effects of the major FA that change as TFA are lowered or removed. For 5 wk, 50 normocholesterolemic men were fed controlled diets providing approximately 15% of energy from protein, 39% from fat, and 46% from carbohydrate in a randomized, 6×6, crossover design. Eight percent of energy was replaced across diets with the following: carbohydrate (CHO) (1∶1 simple to complex); oleic acid (OL); TFA; stearic acid (STE); TFA/STE (4% of energy from each); carbon 12∶0 16∶0 saturated FA (LMP). LDL cholesterol concentrations (mmol/l) were as follows (different superscripts indicate significance at P≤0.01): OL 2.95a; CHO 3.05a,b; STE 3.10b,c; LMP 3.21c,d; TFA+STE 3.32d,e; and TFA 3.36e. HDL cholesterol concentrations (mmol/L) were as allows: STE 1.16a; IFA 1.16a,b; TFA/STE 1.17a,b; CHO 1.19b; OL 1.24c; and LMP 1.30d. Triacylglycerides were highest after STE (1.13) and lowest after OL (0.88) (P<0.001). Thus, compared to the carbohydrate control diet, TFA raised LDL cholesterol at least equivalent to LMP but had no effect on HDI cholesterol; STE had no effect on LDL cholesterol but lowered HDL cholesterol; LMP raised both LDL cholesterol and HDL cholesterol; and oleic acid raised HDL cholesterol but had no effect on LDL cholesterol.

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Abbreviations

apo:

plasma apolipoprotein

BHNRC:

Beltsville Human Nutrition Research Center

BMI:

body mass index

CHO, LMP, OL, STE, and TFA:

basal diet enriched with carbohydrate, saturated FA (as the sum lauric +myristic+palmitic acids) oleic acid, stearic acid, or trans monunsaturated

FA:

respectively

CVD:

cardiovascular disease

en%:

percentage of dietary energy

HDL-C:

plasma high density lipoprotein cholesterol

LDL-C:

plasma low density lipoprotein cholesterol

LMP:

sum of lauric (L), myristic (M), and palmitic (P) FA

OL:

oleic acid

STE:

stearic acid

TC:

total plasma cholesterol

TFA:

trans monounsaturated FA

TFA/STE:

basal diet plus 4% of energy (4 en%) added as trans fatty acids and 4 en% as stearic acid

TG:

triacylglycerides

References

  1. Judd, J.T., Clevidence, B.A., Muesing, R.A., Wittes, J., Sunkin, M.E., and Podezasy, J.J. (1994) Dietary trans Fatty Acids: Effects on Plasma Lipids and Lipoproteins of Healthy Men and Women, Am. J. Clin. Nutr. 59, 861–868.

    PubMed  CAS  Google Scholar 

  2. The British Nutrition Foundation (1995) Report of the British Nutrition Foundation Task Force. Trans Fatty Acids, The British Nutrition Foundation, 1995, London.

    Google Scholar 

  3. American Society for Clinical Nutrition/American Institute of Nutrition (1996) Task Force on trans Fatty Acids. Position Paper on Trans Fatty Acids, Am. J. Clin. Nutr. 63, 663–670.

    Google Scholar 

  4. Food and Agriculture Organization of the United Nations, and the World Health Organization (1994) Isomeric Fatty Acids, Fats and Oils in Human Nutrition. FAO Food and Nutrition Paper 57, Food and Agriculture Organization of the United Nations, Rome.

    Google Scholar 

  5. International Society for the Study of Fatty Acids and Lipids (1995) Danish Nutrition Council Report on trans Fatty Acids, ISSFAL Newsletter 2(3), 5–7.

    Google Scholar 

  6. Hinkelman, K., and Kempthorne, O. (1994) Design and Analysis of Experiments, Vol. 1, John Wiley & Sons, New York.

    Google Scholar 

  7. Society of Actuaries and Association of Life Insurance Medical Directors of America (1980) 1979 Build Study. Weight of Insured Persons in the United States Associated with Lowest Mortality, Association of Life Insurance Medical Directors of America, Philadelphia.

    Google Scholar 

  8. U.S. Department of Agriculture, Human Nutrition Information Service (1976–1990) Composition of Foods, Agriculture Handbook No. 8, Sections 1–22, U.S. Government Printing Office, Washington, DC.

    Google Scholar 

  9. U.S. Department of Agriculture, Agricultural Research Service (1997) Data Tables: Results from USDA’s Continuing Survey of Food Intakes by Individuals and 1994–96 Diet and Health Knowledge Survey, Riverdale, MD.

  10. Small, D.M. (1991) The Effects of Glyceride Structure on Absorption and Metabolism, in Annual Review of Nutrition (Olson, R.E., Bier, D.M., and McCormick, D.B., eds.), Vol. 11, Annual Reviews, Palo Alto, CA.

    Google Scholar 

  11. Hainline, A., Karon, J., and Lippel, K. (eds.) (1982) Mannual of Laboratory Operations, Lipid Research Clinics Program, Lipid and Lipoprotein Analysis, 2nd edn., National Heart, Lung, and Blood Institute, NIH, DHHS, Bethesda, MD.

    Google Scholar 

  12. Gidez, L.I., Miller, G.J., Burstein, M., Slagle, S., and Eder, H.A. (1982) Separation and Quantitation of Subclasses of Human Plasma High-Density Lipoproteins by a Simple Precipitation Procedure, J. Lipid Res. 23, 1206–1223.

    PubMed  CAS  Google Scholar 

  13. Friedewald, W.T., Levy, R.I., and Fredrickson, D.S. (1972) Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma Without Use of the Preparative Ultracentrifuge, Clin. Chem. 18, 499–502.

    PubMed  CAS  Google Scholar 

  14. Littell, R.C., Milliken, G.A., Stroup, W.W., and Wolfinger, R.D. (1996) SAS System for Mixed Models, SAS Institute, Cary, NC, 1996.

    Google Scholar 

  15. Temme, E.H., Mensink, R.P., and Hornstra, G. (1996) Comparison of the Effects of Diets Enriched in Lauric, Palmitic, or Oleic Acids on Serum Lipids and Lipoproteins in Healthy Women and Men, Am. J. Clin. Nutr. 63, 897–903.

    PubMed  CAS  Google Scholar 

  16. Mensink, R.P., and Katan, M.B. (1990) Effect of Dietary trans Fatty Acids on High-Density and Low-Density Lipoprotein Cholesterol Levels in Healthy Subjects, N. Engl. J. Med. 323, 439–445.

    Article  PubMed  CAS  Google Scholar 

  17. Zock, P.L., Katan, M.B., and Mensink, R.P. (1995) Dietary trans Fatty Acids and Lipoprotein Cholesterol, Am. J. Clin. Nutr. 61, 617.

    PubMed  CAS  Google Scholar 

  18. Allison, D.B., Egan, K., Barrai, L.M., Caughman, C., Infante M., and Heimbach, J.T. (1999) Estimated Intakes of trans Fatty and Other Fatty Acids in the U.S. Population, J. Am. Diet. Assoc. 99, 166–174.

    Article  PubMed  CAS  Google Scholar 

  19. Grundy, S.M. (1994) Lipids and Cardiovascular Disease, in Nutrition and Disease, Update: Heart Disease (Kritchevsky, D., and Carroll, K.K., eds.), pp. 211–279, AOCS Press, Champaign,

    Google Scholar 

  20. Grundy, S.M., and Denke, M.A. (1990) Dietary Influences on Serum Lipids and Lipoproteins, J. Lipid Res. 31, 1149–1172.

    PubMed  CAS  Google Scholar 

  21. Lichtenstein, A.H., Ausman, L.M., Jalbert, S.M., and Schaefer, E.J. (1999) Effects of Different Forms of Dietary Hydrogenated Fats on Serum Lipoprotein Cholesterol Levels, N. Engl. J. Med. 340, 1933–1940.

    Article  PubMed  CAS  Google Scholar 

  22. Judd, J.T., Baer, D.J., Clevidence, B.A., Muesing, R.A., Chen, S.C., Weststrate, J.A., Meijer, G.W., Wittes, J., Lichtenstein, A.H., Vilella-Bach, M., and Schaefer, E.J. (1998) Effects of Margarine Compared with Those of Butter on Blood Lipid Profiles Related to Cardiovascular Disease Risk Factors in Normolipemic Adults Fed Controlled Diets, Am. J. Clin. Nutr. 68, 768–777.

    PubMed  CAS  Google Scholar 

  23. Ahuja, J.K.C., Exler, J., Cahil, P.S., and Raper, N. (1997) Individual Fatty Acid Intakes: Results from 1995 Continuing Survey of Food Intakes by Individuals, U.S. Department of Agriculture, Agricultural Research Service, Riverdale, MD.

    Google Scholar 

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Authors and Affiliations

  1. Nutrition Department, Pennsylvania State University, University Park, Pennsylvania

    Penny Kris-Etherton

  2. Lipid Research Clinic, The George Washington University Medical Center, Washington DC

    Richard A. Muesing

  3. Statistics Collaborative, Washington, DC

    Marika Iwane

  4. Diet and Human Performance Laboratory, BHNRC, Building 308, Room 214, BARC-East, 20705, Beltsville, MD

    Joseph T. Judd, David J. Baer & Beverly A. Clevidence

Authors
  1. Joseph T. Judd
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  2. David J. Baer
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  3. Beverly A. Clevidence
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  4. Penny Kris-Etherton
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  5. Richard A. Muesing
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  6. Marika Iwane
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Correspondence to Joseph T. Judd.

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Judd, J.T., Baer, D.J., Clevidence, B.A. et al. Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men. Lipids 37, 123–131 (2002). https://doi.org/10.1007/s11745-002-0871-9

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  • DOI: https://doi.org/10.1007/s11745-002-0871-9

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