Abstract
The last quarter of the 20th century was characterized by an increase in the consumer's interest in the nutritional aspects of health. As a result, governments began to develop dietary guidelines in addition to the traditional recommended dietary allowances, which have been superseded now by dietary reference intakes. In addition to governments, various scientific societies and nongovernmental organizations have issued their dietary advice to combat chronic diseases and obesity. Human beings evolved on a diet that was balanced in n−6 and n−3 essential fatty acid intake, whereas Western diets have a ratio of n−6/n−3 of 16.74. The scientific evidence is strong for decreasing the n−6 and increasing the n−3 intake to improve health throughout the life cycle. This paper discusses the reasons for this change and recommends the establishment of a nutrition and Food Policy, instead of a Food and Nutrition Policy, because the latter subordinates the nutritional aspects to the food policy aspects. Nutrition and food planning comprise a tool of nutrition and food policy, whose objectives are the achievement of the adequate nutrition of the population as defined by nutritional science. The scientific basis for the development of a public policy to develop dietary recommendations for essential fatty acids, including a balanced n−6/n−3 ratio is robust. What is needed is a scientific consensus, education of professionals and the public, the establishment of an agency on nutrition and food policy at the national level, and willingness of governments to institute changes. Education of the public is essential to demand changes in the food supply
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Abbreviations
- AA:
-
arachidonic acid
- ALA:
-
α-linolenic acid
- DRI:
-
dietary reference intakes
- EFA:
-
essential fatty acids
- LA:
-
linoleic acid
- RDA:
-
recommended dietary allowances
References
Simopoulos, A.P. (1979) The Scientific Basis of the “Goals”: What Can Be Done Now? J. Am. Diet. Assoc. 74, 539–542.
Food and Nutrition Board (1997) Uses of Dietary Reference Intakes, Ch. 9. National Academy of Sciences, Washington, DC.
Truswell, A.S. (1995) Dietary Guidelines: Theory and Practice, Proc. Nutr. Soc. Aust. 19, 1–10.
Truswell, A.S. (1989) Objectives and Uses of Dietary Guidelines with Emphasis on the Australian Experience, in Dietary Guidelines: Proceedings of an International Conference (Latham, M.C., and van Veen, M.S., eds.), Toronto, 1988, Cornell University Int. Nutr. Monogr. Ser. No. 21.
Simopoulos, A.P. (ed.) (1989) First International Conference on Nutrition and Fitness, Am. J. Clin. Nutr. 49 (Suppl.), 912–1140.
Simopoulos, A.P. (1989) Nutrition and Fitness, J. Am. Med. Assoc. 26, 2862–2863.
Lara-Pantin, E. (1989) Policies and Programs in Nutrition and Physical Fitness in Venezuela, Am. J. Clin. Nutr. 49 (Suppl.), 1057–1059.
Pena, M., and Bacallao J. (eds.) (2000) Obesity and Poverty, A New Public Health Challenge, Pan American Health Organization, Scientific Publication No. 576, Washington, DC.
Simopoulos, A.P. (ed.) (1993) Nutrition and Fitness in Health and Disease, World Review of Nutrition and Dietetics, Vol. 72, pp. 1–244, S. Karger, Basel
Simopoulos, A.P. (ed.) (1997) Nutrition and Fitness. Evolutionary Aspects. Children's Health, Programs and Policies, World Review of Nutrition and Dietetics, Vol. 81, pp. 1–172, S. Karger, Basel.
Simopoulos, A.P., and Pavlou, K.N. (eds.) (1997) Nutrition and Fitness, Metabolic and Behavioral Aspects in Health and Disease, World Review of Nutrition and Dietetics, Vol. 82, pp. 1–266, S. Karger, Basel.
Burr, G.O., and Burr, M.M. (1929) A New Deficiency Disease Produced by the Rigid Exclusion of Fat from the Diet, J. Biol. Chem. 82, 345–367.
Burr, G.O., and Burr, M.M. (1930) On the Nature and Role of Fatty Acids Essential in Nutrition, J. Biol. Chem. 86, 587–621
Bang, H.O., and Dyerberg, J. (1972) Plasma Lipids and Lipoproteins in Greenlandic West-Coast Eskimos, Acta Med. Scand. 192, 85–94.
Dyerberg, J., Bang, H.O., and Hjorne, N. (1976) Fatty Acid Composition of the Plasma Lipids in Greenland Eskimos. Am. J. Clin. Nutr. 28, 958–966.
Bang, H.O., Dyerberg, J., and Hjorne, N. (1976) The Composition of Food Consumed by Greenland Eskimos, Acta Med. Scand. 200, 69–73.
Dyerberg, J., Bang, H.O., and Stofferson, E. (1978) Eicosapentaenoic Acid and Prevention of Thrombosis and Atherosclerosis. Lancet 2, 117–119.
Dyerberg, J., and Bang, H.O. (1979) Haemostatic Function and Platelet Polyunsaturated Fatty Acids in Eskimos, Lancet 2, 433–435.
Simopoulos, A.P. (1991) Omega-3 Fatty Acids in Health and Disease and in Growth and Development, Am. J. Clin. Nutr. 54, 438–463.
Simopoulos, A.P., Kifer, R.R., and Martin, R.E. (eds.) (1986) Health Effects of Polyunsaturated Fatty Acids in Seafoods. Academic Press, Orlando.
Galli, C., and Simopoulos, A.P. (eds.) (1989) Dietary ω-3 and ω-6 Fatty Acids: Biological Effects and Nutritional Essentiality, Plenum Publishing, New York.
Simopoulos, A.P., Kifer, R.R., Martin, R.E., and Barlow, S.M. (1991) Health Effects of ω-3 Polyunsaturated Fatty Acids in Seafoods, World Review of Nutrition and Dietetics, Vol. 66, S. Karger, Basel.
Galli, C., Simopoulos, A.P., and Tremoli, E. (eds.) (1994) Fatty Acids and Lipids: Biological Aspects, World Review of Nutrition and Dietetics, Vol. 75, S. Karger, Basel.
Galli, C., Simopoulos, A.P., and Tremoli, E. (eds.) (1994) Effects of Fatty Acids and Lipids in Health and Disease, World Review of Nutrition and Dietetics, Vol. 76, S. Karger, Basel.
Salem, N., Jr., Simopoulos, A.P., Galli, C., Lagarde, M., and Knapp, H. (eds.) (1996) Proceedings of the 2nd Congress of ISSFAL on Fatty Acids and Lipids from Cell Biology to Human Disease, Lipids 31 (Suppl.), S1–S326.
Lagarde, M., Spector, A.A., Galli, C., Hamazaki, T., and Knapp, H.R. (1999) Proceedings of the 3rd Congress of ISSFAL on Fatty Acids and Lipids from Cell Biology to Human Disease, Lipids 34 (Suppl.), S1-S350.
de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J.L., Monjaud, I., Guidollet, J., Touboul, P., and Delaye, J. (1994) Mediterranean Alpha-Linolenic Acid-Rich Diet in the Secondary Prevention of Coronary Heart Disease, Lancet 343, 1454–1459.
Renaud, S., de Lorgeril, M., Delaye, J., Guidollet, J., Jacquard, F., Mamelle, N., Martin, J.L., Monjaud, I., Salen, P., and Touboul, P. (1995) Cretan Mediterranean Diet for Prevention of Coronary Heart Disease, Am. J. Clin. Nutr. 61 (Suppl.) 1360S-1367S.
de Lorgeril, M., and Salen, P. (2000) Modified Cretan Mediterranean Diet in the Prevention of Coronary Heart Disease and Cancer, in Mediterranean Diets (Simopoulos, A.P., and Visioli, F., eds.), World Review of Nutrition and Dietetics, Vol. 87, S. Karger, Basel.
Burr, M.L., Fehily, A.M., Gilbert, J.F., Rogers, S., Holliday, R.M., Sweetnam, P.M., Elwood, P.C., and Deadman, N.M. (1989) Effect of Changes in Fat, Fish and Fibre Intakes on Death and Myocardial Reinfarction: Diet and Reinfarction Trial (DART), Lancet 2, 757–761.
Singh, R.B., Rastogi, S.S., Verma, R., Laxmi, B., Singh, R., Ghosh, S., and Niaz, M.A. (1992) Randomized Controlled Trial of Cardioprotective Diet in Patients with Recent Acute Myocardial Infarction: Results of One year Follow Up. Br. Med. J. 304, 1015–1019.
Singh, R.B., Niaz, M.A., Sharma, J.P., Kumar, R., Rastogi, V., and Moshiri, M. (1997) Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil and Mustard Oil in Patients with Suspected Acute Myocardial Infarction: The Indian Experiment of Infarct Survival—4, Cardiovasc. Drugs Ther. 11, 485–491.
Simopoulos, A.P. (1997) Omega-3 Fatty Acids in the Prevention-Management of Cardiovascular Disease, Can. J. Physiol. Pharmacol. 75, 234–239.
GISSI-Prevenzione Investigators (1999) Dietary Supplementation with n−3 Polyunsaturated Fatty Acids and Vitamin E After Myocardial Infarction: Results of the GISSI-Prevenzione Trial, Lancet 354, 447–455.
Simopoulos, A.P. (1998) Overview of Evolutionary Aspects of 43 Fatty Acids in the Diet, in The Return of ω-3 Fatty Acids into the Food Supply, I. Land-Based Animal Food Products and Their Health Effects (Simopoulos, A.P., ed.), World Review of Nutrition and Dietetics, Vol. 83, pp. 1–11, S. Karger, Basel.
Eaton, S.B., Eaton, S.B., III, Sinclair, A.J., Cordain, L., and Mann, N.J. (1998) Dietary Intake of Long-Chain Polyunsaturated Fatty Acids During the Paleolithic, in The Return of ω-3 Fatty Acids into the Food Supply, I. Land-Based Animal Food Products and Their Health Effects (Simopoulos, A.P., ed.), World Review of Nutrition and Dietetics, Vol. 83, pp. 12–23, S. Karger, Basel,
Eaton, S.B., Konner, M., and Shostak, M. (1988) Stone Agers in the Fast Lane: Chronic Degenerative Diseases in Evolutionary Perspective. Am. J. Med. 84, 739–749.
Eaton, S.B., and Konner, M. (1985) Paleolithic Nutrition. A Consideration of Its Nature and Current Implications, N. Engl. J. Med. 312, 283–289.
Simopoulos, A.P. (1999) Genetic Variation and Evolutionary Aspects of Diet, in Antioxidants in Nutrition and Health, (Papas, A., ed.), pp. 65–88, CRC Press, Boca Raton.
Cordain, L. (1999) Cereal Grains: Humanity's Double-Edged Sword, in Evolutionary Aspects of Nutrition and Health, Diet Exercise, Genetics and Chronic Disease (Simopoulos, A.P., ed.), World Review of Nutrition and Dietetics, Vol. 84, pp. 19–73, S. Karger, Basel.
Crawford, M.A. (1968) Fatty Acid Ratios in Free-Living and Domestic Animals, Lancet i, 1329–1333.
Simopoulos, A.P., and Salem, N., Jr. (1989) n−3 Fatty Acids in Eggs from Range-Fed Greek Chickens, N. Engl. J. Med. 321, 1412.
Simopoulos, A.P., and Salem, N., Jr. (1992) Egg Yolk as a Source of Long-Chain Polyunsaturated Fatty Acids in Infant Feeding, Am. J. Clin. Nutr. 55, 411–414.
van Vliet, T., and Katan, M.B. (1990) Lower Ratio of n−3 to n−6 Fatty Acids in Cultured Than in Wild Fish, Am. J. Clin. Nutr. 51, 1–2.
Simopoulos, A.P., and Salem, N., Jr. (1986) Purslane: A Terrestrial Source of Omega-3 Fatty Acids, N. Engl. J. Med. 315, 833.
Simopoulos, A.P., Norman, H.A., Gillaspy, J.E., and Duke, J.A. (1992) Common Purslane: A Source of Omega-3 Fatty Acids and Antioxidants. J. Am. Coll. Nutr. 11, 374–382.
Simopoulos, A.P., Norman, H.A., and Gillaspy, J.E. (1995) Purslane in Human Nutrition and Its Potential for World Agriculture, In Plants in Human Nutrition (Simopoulos, A.P., ed.), World Review of Nutrition and Dietetics, Vol. 77, pp. 47–74 S. Karger, Basel.
Guil, J.L., Torija, M.E., Gimenez, J.J., and Rodriguez, I. (1996) Identification of Fatty Acids in Edible Wild Plants by Gas Chromatography, J. Chromotogr. 719, 229–235.
Sugano, M., and Hirahara, F. (2000) Polyunsaturated Fatty Acids in the Food Chain in Japan, Am. J. Clin. Nutr. 71 (Suppl.), 189S-196S.
Sanders, T.A.B. (2000) Polyunsaturated Fatty Acids in the Food Chain in Europe, Am. J. Clin. Nutr. 71 (Suppl.), 176S-178S.
Simopoulos, A.P., and Robinson, J. (1999) The Omega Diet. The Lifesaving Nutritional Program Based on the Diet of the Island of Crete, HarperCollins, New York
Simopoulos, A.P., and Visioli, F. (2000) Mediterranean Diets, World Review of Nutrition and Dietetics, Vol. 87, S. Karger, Basel.
Pietinen, P., Vartiainen, E., Seppanen, R., Aro, A., and Puska, P. (1996) Changes in Diet in Finland from 1972 to 1992: Impact on Coronary Heart Disease Risk, Prev. Med. 25, 243–250.
Scientific Review Committee (1990) Nutrition Recommendations, Minister of National Health and Welfare Canada, Ottawa, H49-42/1990E.
British Nutrition Foundation (1992) Unsaturated Fatty Acids Nutritional and Physiological Significance: The Report of the British Nutrition Foundation's Task Force, Chapman & Hall. New York
World Health Organization (1995) Fats and Oils in Human Nutrition: Report of a Joint Expert Consultation. Food and Agriculture Organization of the United Nationas and the World Health Organization, FAO Food Nutr. Paper 57, pp. 1–147, Rome.
Simopoulos, A.P., Leaf, A., and Salem, N., Jr. (1999) Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids, Ann. Nutr. Metab. 43, 127–130.
Simopoulos, A.P. (1998) The Return of Omega-3 Fatty Acids into the Food Supply. I. Land-Based Animal Food Products and Their Health Effects. World Review of Nutrition and Dietetics, Vol. 83, S. Karger, Basel.
Simopoulos, A.P. (1999) New Products from the Agri-Food Industry: The Return of n−3 Fatty Acids into the Food Supply, Lipids 34 (Suppl.), S297-S301.
Crawford, M., Galli, C., Visioli, F., Renaud, S., Simopoulos, A.P., and Spector, A.A. The Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition, Ann. Nutr. Metab. 44, 263–265.
Warden, J. (1998) UK Health Departments to Lead on Food Safety, Br. Med. J. 316, 171.
UK Government White Paper (1998) The Food Standards Agency: A Time for Change Paves the Way for Legislation. London.
Simopoulos, A.P. (1989) The Future Direction of Nutrition Research: A Nutrition and Food Sciences Agency Is the Key to Progress, J. Nutr. 119, 137–139.
Reeves, J.B., and Weihrauch, J.L. (1979) Composition of Foods, Agriculture Handbook No. 8-4, U.S. Department of Agriculture, Washington, DC.
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Simopoulos, A.P. n−3 fatty acids and human health: Defining strategies for public policy. Lipids 36 (Suppl 1), S83–S89 (2001). https://doi.org/10.1007/s11745-001-0687-7
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DOI: https://doi.org/10.1007/s11745-001-0687-7