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The Hordaland Homocysteine Studies

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Lipids

Abstract

The Hordaland Homocysteine Study is a population-based screening of total plasma homocysteine (tHcy) in ∼18,000 men and women aged 40–67 yr that took place in 1992–1993 in the county of Hordaland in Western Norway. In this cohort, tHcy was associated with several physiologic and life-style factors, including age and gender, blood pressure, serum cholesterol, smoking, alcohol and coffe consumption, physical activity, diet, and vitamin status. All associations with established cardiovascular risk factors were in the direction expected to confer increased risk. In a subset of 5,883 women aged 40–42 yr, tHcy was associated with previous pregnancy outcomes, including preeclampsia, placental abruption, and neural tube defects. This article reviews the published results from the Hordaland Homocysteine Study in the light of relevant literature. The Hordaland Homocysteine cohort will be used for future investigations of the stability of tHcy and vitamin status over time, and to investigate associations with mortality and morbidity including cancer incidence.

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Abbreviations

CVD:

cardiovascular disease

HPLC:

high-performance liquid chromatography

MTHFR:

methylenetetrahydrofolate reductase

tCys:

total cysteine

tHcy:

total homocysteine

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Authors and Affiliations

  1. LOCUS for Homocysteine and Related Vitamins, Armauer Hansens hus, University of Bergen, 5021, Bergen, Norway

    Per Magne Ueland, Ottar Nygård, Stein Emil Vollset & Helga Refsum

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  1. Per Magne Ueland
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  2. Ottar Nygård
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  3. Stein Emil Vollset
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  4. Helga Refsum
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Correspondence to Per Magne Ueland.

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Ueland, P.M., Nygård, O., Vollset, S.E. et al. The Hordaland Homocysteine Studies. Lipids 36 (Suppl 1), S33–S39 (2001). https://doi.org/10.1007/s11745-001-0679-7

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