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Effect of Amino Acids and Glycyl Dipeptides on Micellization of Antibacterial Drug Domiphen Bromide

  • Original Article
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Journal of Surfactants and Detergents

Abstract

The effects of amino acids (glycine, l-alanine, l-valine, l-leucine) and glycyl dipeptides (glycylglycine, glycyl-l-valine, glycyl-l-leucine) on the micellization behaviour of antibacterial drug domiphen bromide in aqueous solution as a function of temperature were studied by both conductivity and fluorescence spectroscopy. Critical micellar concentration, degree of counterion dissociation (α), limiting molar conductivity (Λ 0), and a series of thermodynamic parameters of micellization of domiphen bromide have been calculated from the specific conductivity data. The I 1/I 3 ratios associated with pyrene fluorescence vibronic bands were used to interpret the variation of micropolarity caused by the interactions between domiphen bromide and amino acids/glycyl dipeptides. The mean aggregation number of domiphen bromide was determined by a fluorescence quenching method. Effects of temperature, concentration, and alkyl chain length of the amino acids/glycyl dipeptides on the above properties were examined. Amino acids and glycyl dipeptides effectively enhance the surface activity of domiphen bromide solution. The intensity of amino acid/dipeptide-domiphen bromide interaction increased with the hydrophobicity of the amino acid/glycyl dipeptide.

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Acknowledgements

The project is financially supported by the Natural Science Foundation of China (no. 21573199).

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Authors and Affiliations

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, Henan, People’s Republic of China

    Zhenning Yan, Yunxia Kang, Xiangli Wen, Cuiying Xu & Wenwen Chu

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  1. Zhenning Yan
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  2. Yunxia Kang
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  3. Xiangli Wen
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Correspondence to Zhenning Yan.

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Yan, Z., Kang, Y., Wen, X. et al. Effect of Amino Acids and Glycyl Dipeptides on Micellization of Antibacterial Drug Domiphen Bromide. J Surfact Deterg 20, 391–400 (2017). https://doi.org/10.1007/s11743-017-1925-0

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  • DOI: https://doi.org/10.1007/s11743-017-1925-0

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