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A 40-year-old man with recurrent fainting, hypotension, lower limb edema and oliguria with body weight gain and secondary erythrocytosis

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References

  1. Gousseff M, Arnaud L, Lambert M, Hot A, Hamidou M, Duhaut P, Papo T, Soubrier M, Ruivard M, Malizia G, Tieulié N, Rivière S, Ninet J, Hatron PY, Amoura Z, for the Capillary Leak Syndrome Registry (2011) The systemic capillary leak syndrome: a case series of 28 patients from a European registry. Ann Intern Med 154:464–471

    PubMed  Google Scholar 

  2. Clarkson B, Thompson D, Horwitz M, Luckey EH (1960) Cyclical edema and shock due to increased capillary permeability. Am J Med 29:193–216

    Article  PubMed  CAS  Google Scholar 

  3. Atkinson JP, Waldmann TA, Stein SF, Gelfand JA, Macdonald WJ, Heck LW, Cohen EL, Kaplan AP, Frank MM (1977) Systemic capillary leak syndrome and monoclonal IgG gammopathy; studies in a sixth patient and a review of the literature. Medicine (Baltimore) 56:225–239

    CAS  Google Scholar 

  4. Dhir V, Arya V, Malav IC, Suryanarayanan BS, Gupta R, Dey AB (2007) Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years. Intern Med 46:899–904

    Article  PubMed  Google Scholar 

  5. Teelucksingh S, Padfield PL, Edwards CR (1990) Systemic capillary leak syndrome. Q J Med 75:515–524

    PubMed  CAS  Google Scholar 

  6. Lilly CM, Silverman ES, Sheffer AL (2002) Systemic capillary leak syndrome, leukotrienes, and anaphylaxis. J Intensive Care Med 17:189–194

    Article  Google Scholar 

  7. Cicardi M, Gardinali M, Bisiani G, Rosti A, Allavena P, Agostoni A (1990) The systemic capillary leak syndrome: appearance of interleukin-2-receptor-positive cells during attacks. Ann Intern Med 113:475–477

    PubMed  CAS  Google Scholar 

  8. Navarro C, Garcia-Bragado F, Lima J, Fernandez JM (1990) Muscle biopsy findings in systemic capillary leak syndrome. Hum Pathol 21:297–301

    Article  PubMed  CAS  Google Scholar 

  9. Zhang W, Ewan PW, Lachmann PJ (1993) The paraproteins in systemic capillary leak syndrome. Clin Exp Immunol 93:424–429

    Article  PubMed  CAS  Google Scholar 

  10. Cicardi M, Berti E, Caputo V, Radice F, Gardinali M, Agostoni A (1997) Idiopathic capillary leak syndrome: evidence of CD8-positive lymphocytes surrounding damaged endothelial cells. J Allergy Clin Immunol 99:417–419

    Article  PubMed  CAS  Google Scholar 

  11. Assaly R, Olson D, Hammersley J, Fan PS, Liu J, Shapiro JI, Kahaleh MB (2001) Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome. Chest 120:1301–1308

    Article  PubMed  CAS  Google Scholar 

  12. Druey KM, Greipp PR (2010) Narrative review: the systemic capillary leak syndrome. Ann Intern Med 153:90–98

    PubMed  Google Scholar 

  13. Van Hinsberg VWM, Van Nieuw Amerongen GP (2003) Endothelial hyperpermeability in vascular leakage. Vasc Pharmacol 39:171–172

    Article  Google Scholar 

  14. Lambert M, Launay D, Hachulla E, Morell-Dubois S, Soland V, Queyrel V, Fourrier F, Hatron PY (2008) High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome. Crit Care Med 36:2184–2187

    Article  PubMed  CAS  Google Scholar 

  15. Dowden AM, Rullo OJ, Aziz N, Fasano MB, Chatila T, Ballas ZK (2009) Idiopathic systemic capillary leak syndrome: novel therapy for acute attacks. J Allergy Clin Immunol 124:1111–1113

    Article  PubMed  Google Scholar 

  16. Perosa F, Prete M, Racanelli V, Dammacco F (2010) CD20-depleting therapy in autoimmune diseases: from basic research to the clinic. J Intern Med 267:260–277

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by grants from the Italian Ministry for University and Research (COFIN, Nos. 20085MSFH2-003), Rome, Italy.

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Authors and Affiliations

  1. Department of Medical and Surgical Sciences, Padua University Medical School, via Giustiniani 2, 35128, Padova, Italy

    Giulia Berti de Marinis, Irene Bertozzi, Emanuele Allemand, Fabiana Tezza, Maria Luigia Randi & Fabrizio Fabris

  2. Nephrology Division, Padua City and University Hospital, Padova, Italy

    Agostino Naso

Authors
  1. Giulia Berti de Marinis
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  2. Irene Bertozzi
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  3. Emanuele Allemand
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  4. Fabiana Tezza
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  5. Maria Luigia Randi
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  6. Agostino Naso
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  7. Fabrizio Fabris
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Corresponding author

Correspondence to Fabrizio Fabris.

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Berti de Marinis, G., Bertozzi, I., Allemand, E. et al. A 40-year-old man with recurrent fainting, hypotension, lower limb edema and oliguria with body weight gain and secondary erythrocytosis. Intern Emerg Med 7, 453–456 (2012). https://doi.org/10.1007/s11739-011-0692-6

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  • DOI: https://doi.org/10.1007/s11739-011-0692-6

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