Abstract
The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.
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Acknowledgements
The authors acknowledge funding from Medical Research Scotland (S.B.: 879-2015) and an ERC Consolidator Grant (DYNAFLUORS, M. V.: 771443). This work was also supported by National Research Foundation funded by the Ministry of Science, ICT & Future Planning, South Korea (J. S. L.: NRF-2018M3A9H4079286, NRF-2020R1A2C2004422).
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de Moliner, F., Biazruchka, I., Konsewicz, K. et al. Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores. Front. Chem. Sci. Eng. 16, 128–135 (2022). https://doi.org/10.1007/s11705-021-2080-8
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DOI: https://doi.org/10.1007/s11705-021-2080-8